Study of viral pathogenesis in humanized mice

被引：13

作者：

Gaska, Jenna M. ^{[1
]}

Ploss, Alexander ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

CURRENT OPINION IN VIROLOGY | 2015年 / 11卷

基金：

美国国家卫生研究院;

关键词：

DENGUE-VIRUS-INFECTION; PRINCIPAL TARGET-CELLS; MOUSE MODEL; T-CELLS; HEPATITIS-B; HUMAN CYTOMEGALOVIRUS; HUMAN HEPATOCYTES; ANIMAL-MODELS; HIV LATENCY; LIVER;

D O I：

10.1016/j.coviro.2015.01.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. The improvement of humanized mouse models over the past 30 years has greatly facilitated researchers' abilities to study host responses to viral infections in a cost effective and ethical manner. From HIV to hepatotropic viruses to Middle East Respiratory Syndrome coronavirus, humanized mice have led to the identification of factors crucial to the viral life cycle, served as an outlet for testing candidate therapies, and improved our abilities to analyze human immune responses to infection. In tackling both new and old viruses as they emerge, humanized mice will continue to be an indispensable tool.

引用

页码：14 / 20

页数：7

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