Antibacterial quaternary ammonium agents: Chemical diversity and biological mechanism

被引：70
作者：
Dan, Wenjia [1 ]
Gao, Jixiang [1 ]
Qi, Xiaohui [1 ]
Wang, Junru [2 ,4 ]
Dai, Jiangkun [1 ,3 ]
机构：
[1] Weifang Med Univ, Sch Life Sci & Technol, Weifang, Shandong, Peoples R China
[2] Northwest A&F Univ, Coll Chem & Pharm, Xianyang, Shaanxi, Peoples R China
[3] Weifang Med Univ, Sch Life Sci & Technol, Room 21408,Bldg Minxing,Baotong West St, Weifang, Peoples R China
[4] Northwest A&F Univ, Coll Chem & Pharm, Room C206,Bldg Sci, Yangling, Shaanxi, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2022年 / 243卷
基金：
中国国家自然科学基金;
关键词：
Quaternary ammonium compounds; Antibacterial; Structure -activity relationships; Mechanism; ANTIMICROBIAL ACTIVITY; SMALL MOLECULES; IN-VITRO; DERIVATIVES; BACTERIAL; COMPOUND; ANALOGS; BROAD; ANTIBIOTICS; AMPHIPHILES;
D O I：
10.1016/j.ejmech.2022.114765
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bacterial infections have seriously threatened public health especially with the increasing resistance and the clifflike decline of the number of newly approved antibacterial agents. Quaternary ammonium compounds (QACs) possess potent medicinal properties with 95 successfully marketed drugs, which also have a long history as antibacterial agents. In this review, we summarize the chemical diversity of antibacterial QACs, divided into chain-like and aromatic ring, reported over the past decade (2012 to mid-2022). Additionally, the structureactivity relationships, mainly covering hydrophobicity, charges and skeleton features, are discussed. In the cases where sufficient information is available, antibacterial mechanisms including biofilm, cell membrane, and intracellular targets are presented. It is hoped that this review will provide sufficient information for medicinal chemists to discover the new generation of antibacterial agents based on QACs.
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页数：12
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