Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel

被引：10

作者：

Chung, Dong-Il ^{[1
]}

Jeong, Sookwan ^{[2
]}

Dinzouna-Boutamba, Sylvatrie-Danne ^{[1
]}

Yang, Hye-Won ^{[1
]}

Yeo, Sang-Geon ^{[3
]}

Hong, Yeonchul ^{[1
]}

Goo, Youn-Kyoung ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Parasitol & Trop Med, Daegu 70422, South Korea

[2] Headquarters Republ Korea Army, Dept Med, Chungnam, South Korea

[3] Kyungpook Natl Univ, Coll Vet Med, Taegu 702701, South Korea

来源：

MALARIA JOURNAL | 2015年 / 14卷

关键词：

Plasmodium vivax; Multidrug resistant-1 gene; Microsatellite marker; Genetic diversity; LINKAGE DISEQUILIBRIUM; CHLOROQUINE RESISTANCE; MALARIA; MARKERS; POPULATION; EFFICACY; GENE; AMPLIFICATION; TRANSMISSION; PATTERNS;

D O I：

10.1186/s12936-015-0845-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Chloroquine has been administered to the soldiers of the Republic of Korea as prophylaxis against vivax malaria. Recent increase in the number of chloroquine-resistant parasites has raised concern over the chemoprophylaxis and treatment of vivax malaria. Methods: To monitor the development of chloroquine-resistant parasites in the Republic of Korea, analyses of single nucleotide polymorphisms (SNPs) of pvmdr1 and microsatellite markers were performed using samples collected from 55 South Korean soldiers infected with Plasmodium vivax. Results: Four SNPs, F1076L, T529, E1233, and S1358, were identified. Among these, S1358 was detected for the first time in Korea. The microsatellite-based study revealed higher genetic diversity in samples collected in 2012 than in 2011. Conclusions: Taken together, the results indicate that P. vivax with a newly identified SNP of pvmdr1 has been introduced into the Korean P. vivax population. Therefore, continuous monitoring for chloroquine-resistant parasites is required for controlling vivax malaria in the Republic of Korea.

引用

页数：7

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