A new MAFia in cancer

被引：166
作者：
Eychene, Alain
Rocques, Nathalie
Pouponnot, Celio [1 ]
机构：
[1] Ctr Rech, Inst Curie, F-91405 Orsay, France
[2] CNRS, UMR 146, F-91405 Orsay, France
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 09期
关键词：
D O I：
10.1038/nrc2460
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer-overexpression of the large Maf genes promotes the development of multiple myeloma-they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.
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页码：683 / 693
页数：11
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