Stem Cell-Based Therapy in Idiopathic Pulmonary Fibrosis

被引:37
作者
Barczyk, Marek [1 ,3 ]
Schmidt, Matthias [2 ,3 ]
Mattoli, Sabrina [4 ]
机构
[1] Stem Cell Res Ctr, Warsaw, Poland
[2] Discovery & Translat Res Ctr, Munich, Germany
[3] Avail Biomed Res Inst, CH-4052 Basel, Switzerland
[4] Avail Biomed Res Inst, Sci Direct & Project Management, CH-4052 Basel, Switzerland
关键词
Embryonic stem cells; Exosome; Human amnion stem cells; Idiopathic pulmonary fibrosis; Induced pluripotent stem cells; Mesenchymal stem cell; Secretome; Stem cell therapy; MESENCHYMAL STROMAL CELLS; REPETITIVE INTRATRACHEAL BLEOMYCIN; INDUCED LUNG INJURY; II CELLS; ACUTE EXACERBATIONS; IN-VIVO; INTERNATIONAL-SOCIETY; REGENERATIVE MEDICINE; EFFICIENT DERIVATION; EXTRACELLULAR-MATRIX;
D O I
10.1007/s12015-015-9587-7
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Idiopathic pulmonary fibrosis is a progressive fibrosing disorder for which there is no cure and no pharmacological treatment capable of increasing in a meaningful way the survival rate. Lung transplantation remains the only possible treatment for patients with advanced disease, although the increase in 5-year survival is only 45 %. Some preclinical studies have generated promising results about the therapeutic potential of exogenous stem cells. However, two initial clinical trials involving the endobronchial or systemic delivery of autologous adipose tissue-derived or unrelated-donor, placenta-derived mesenchymal stem cells have not convincingly demonstrated that these treatments are acceptably safe. The results of other ongoing clinical trials may help to identify the best source and delivery route of mesenchymal stem cells and to estimate the risk of unwanted effects related to the mesenchymal nature of the transplanted cells. Considering that most of the therapeutic potential of these cells has been ascribed to paracrine signaling, the use of mesenchymal stem cell-derived secretome as an alternative to the transplantation of single cell suspension may circumvent many regulatory and clinical problems. Technical and safety concerns still limit the possibility of clinical applications of other promising interventions that are based on the use of human amnion stem cells, embryonic stem cells or induced pluripotent stem cells to replace or regenerate the dysfunctional alveolar epithelium. We summarize the current status of the field and identify major challenges and opportunities for the possible future integration of stem cell-based treatments into the currently recommended clinical management strategy for idiopathic pulmonary fibrosis.
引用
收藏
页码:598 / 620
页数:23
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