Neurocognitive Effects of Chemotherapy and Endocrine Therapies in the Treatment of Breast Cancer: Recent Perspectives

被引：29
作者：
Walker, Caroline H. [1 ]
Drew, Barbara A. [1 ]
Antoon, James W. [1 ]
Kalueff, Alan V. [1 ]
Beckman, Barbara S. [1 ]
机构：
[1] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA
来源：
CANCER INVESTIGATION | 2012年 / 30卷 / 02期
关键词：
Chemobrain; Cognitive impairment; Breast cancer; Pharmacology; Chemotherapy; RECEIVING ADJUVANT CHEMOTHERAPY; ACUTE LYMPHOBLASTIC-LEUKEMIA; CENTRAL-NERVOUS-SYSTEM; ESTROGEN REPLACEMENT THERAPY; STANDARD-DOSE CHEMOTHERAPY; GLOBAL COGNITIVE FUNCTION; HEALTH INITIATIVE MEMORY; TELOMERE LENGTH; OXIDATIVE STRESS; POSTMENOPAUSAL WOMEN;
D O I：
10.3109/07357907.2011.636116
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
With an estimated 207,090 patients diagnosed with breast cancer in 2010, the role of chemotherapy-induced cognitive impairment is of growing importance. Studies to determine the impact of chemotherapy-induced cognitive impairment have been hindered by difficulties in study-design, in particular, study methodology. Here, we present a review of existing studies and discuss several mechanisms for chemotherapy-induced neurocognitive impairment in breast cancer patients, such as direct neurotoxic injury, telomere shortening, oxidative stress, cytokine dysregulation, estrogen-mediated effects, and the role of certain genetic polymorphisms. Decreased estrogen levels may serve as a link between multiple mechanisms potentiating the effects of the chemotherapy-induced cognitive impairment.
引用
收藏
页码：135 / 148
页数：14
相关论文
共 133 条
[1]   The DNA double-strand break response in the nervous system [J].
Abner, CW ;
McKinnon, PJ .
DNA REPAIR, 2004, 3 (8-9) :1141-1147
[2]   The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy [J].
Ahles, TA ;
Saykin, AJ ;
Noll, WW ;
Furstenberg, CT ;
Guerin, S ;
Cole, B ;
Mott, LA .
PSYCHO-ONCOLOGY, 2003, 12 (06) :612-619
[3]   Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma [J].
Ahles, TA ;
Saykin, AJ ;
Furstenberg, CT ;
Cole, B ;
Mott, LA ;
Skalla, K ;
Whedon, MB ;
Bivens, S ;
Mitchell, T ;
Greenberg, ER ;
Silberfarb, PM .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (02) :485-493
[4]   Psychologic and neuropsychologic functioning of patients with limited small-cell lung cancer treated with chemotherapy and radiation therapy with or without warfarin: A study by the cancer and leukemia group B [J].
Ahles, TA ;
Silberfarb, PM ;
Herndon, J ;
Maurer, LH ;
Kornblith, AB ;
Aisner, J ;
Perry, MC ;
Eaton, WL ;
Zacharski, LL ;
Green, MR ;
Holland, JC .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (05) :1954-1960
[5]   Cognitive function in breast cancer patients prior to adjuvant treatment [J].
Ahles, Tim A. ;
Saykin, Andrew J. ;
McDonald, Brenna C. ;
Furstenberg, Charlotte T. ;
Cole, Bernard F. ;
Hanscom, Brett S. ;
Mulrooney, Tamsin J. ;
Schwartz, Gary N. ;
Kaufman, Peter A. .
BREAST CANCER RESEARCH AND TREATMENT, 2008, 110 (01) :143-152
[6]   Candidate mechanisms for chemotherapy-induced cognitive changes [J].
Ahles, Tim A. ;
Saykin, Andrew J. .
NATURE REVIEWS CANCER, 2007, 7 (03) :192-201
[7]  
Ahles Tim A, 2002, Clin Breast Cancer, V3 Suppl 3, pS84, DOI 10.3816/CBC.2002.s.018
[8]   2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain [J].
Aluise, Christopher D. ;
Miriyala, Sumitra ;
Noel, Teresa ;
Sultana, Rukhsana ;
Jungsuwadee, Paiboon ;
Taylor, Tamara J. ;
Cai, Jian ;
Pierce, William M. ;
Vore, Mary ;
Moscow, Jeffrey A. ;
St Clair, Daret K. ;
Butterfield, Allan .
FREE RADICAL BIOLOGY AND MEDICINE, 2011, 50 (11) :1630-1638
[9]  
[Anonymous], 2010, CANC FACTS FIG 2010
[10]  
Babiak RMV, 1998, CELL BIOCHEM FUNCT, V16, P283, DOI 10.1002/(SICI)1099-0844(1998120)16:4<283::AID-CBF801>3.0.CO
12345678910