Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma

被引：6

作者：

Zhang, Hongzheng ^{[1
]}

Kim, Sungjin ^{[21
]}

Chen, Zhengjia ^{[2
]}

Nannapaneni, Sreenivas ^{[1
]}

Chen, Amy Y. ^{[3
]}

Moore, Charles E. ^{[3
]}

Sica, Gabriel ^{[4
]}

Mosunjac, Marina ^{[4
]}

Nguyen, Minh Ly T. ^{[5
]}

D'Souza, Gypsyamber ^{[6
]}

Carey, Thomas E. ^{[7
]}

Peterson, Lisa A. ^{[7
]}

McHugh, Jonathan B. ^{[7
]}

Graham, Martin ^{[7
]}

Komarck, Christine M. ^{[7
]}

Wolf, Gregory T. ^{[7
]}

Walline, Heather M. ^{[7
,8
]}

Bellile, Emily ^{[9
]}

Riddell, James ^{[10
]}

Pai, Sara I. ^{[11
]}

Sidransky, David ^{[12
]}

Westra, William H. ^{[13
,14
]}

William, William N. ^{[15
]}

Lee, J. Jack ^{[16
]}

El-Naggar, Adel K. ^{[17
]}

Ferris, Robert L. ^{[18
]}

Seethala, Raja ^{[19
]}

Grandis, Jennifer R. ^{[20
]}

Chen, Zhuo Georgia ^{[1
]}

Saba, Nabil F. ^{[1
]}

Shin, Dong M. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA

[2] Emory Univ, Sch Med, Dept Biostat & Bioinformat, Atlanta, GA USA

[3] Emory Univ, Sch Med, Dept Otolaryngol, Atlanta, GA USA

[4] Emory Univ Hosp, Dept Pathol & Lab Med, 1364 Clifton Rd NE, Atlanta, GA 30322 USA

[5] Emory Univ, Sch Med, Dept Internal Med, Atlanta, GA USA

[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[7] Univ Michigan, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Canc Biol Program, Ann Arbor, MI 48109 USA

[9] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA

[10] Univ Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI USA

[11] Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Boston, MA USA

[12] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA

[13] Johns Hopkins Univ, Dept Pathol Otolaryngol, Baltimore, MD USA

[14] Johns Hopkins Univ, Dept Head & Neck Surg, Baltimore, MD USA

[15] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Med Oncol, Houston, TX 77030 USA

[16] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

[17] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Dept Pathol, Houston, TX 77030 USA

[18] Univ Pittsburgh, Sch Med, Dept Otolaryngol, Pittsburgh, PA USA

[19] Univ Pittsburgh, Med Ctr, Dept Pathol & Lab Med, Pittsburgh, PA USA

[20] Univ Calif San Francisco, Dept Otorhinolaryngol Head & Neck Surg, San Francisco, CA 94143 USA

[21] Cedars Sinai Med Ctr, Biostat & Bioinformat Res Ctr, Los Angeles, CA 90048 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 12期

关键词：

biomarkers; head and neck cancer; human immunodeficiency virus (HIV); prognosis; survival; AIDS-DEFINING CANCERS; CIGARETTE-SMOKING; ANTIRETROVIRAL THERAPY; UNITED-STATES; HPV INFECTION; IMMUNE CELLS; RISK-FACTORS; INFLAMMATION; EPIDEMIOLOGY; ASSOCIATIONS;

D O I：

10.1002/hed.24911

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: We examined the prognostic value of a panel of biomarkers in patients with squamous cell carcinoma of the head and neck (SCCHN) who were human immunodeficiency virus (HIV) positive (HIV-positive head and neck cancer) and HIV negative (HIV-negative head and neck cancer). Methods: Tissue microarrays (TMAs) were constructed using tumors from 41 disease site-matched and age-matched HIV-positive head and neck cancer cases and 44 HIV-negative head and neck cancer controls. Expression of tumor biomarkers was assessed by immunohistochemistry (IHC) and correlations examined with clinical variables. Results: Expression levels of the studied oncogenic and inflammatory tumor biomarkers were not differentially regulated by HIV status. Among patients with HIV-positive head and neck cancer, laryngeal disease site (P = .003) and Clavien-Dindo classification IV (CD4) counts <200 cells/mu L (P = .01) were associated with poor prognosis. Multivariate analysis showed that p16 positivity was associated with improved overall survival (OS; P < .001) whereas increased expression of transforming growth factor-beta (TGF-beta) was associated with poor clinical outcome (P = .001). Conclusion: Disease site has significant effect on the expression of biomarkers. Expression of tumor TGF-b could be a valuable addition to the conventional risk stratification equation for improving head and neck cancer disease management strategies.

引用

页码：2433 / 2443

页数：11

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