Gut Microbiota in Liver Disease: What Do We Know and What Do We Not Know?

被引：37
作者：
Jiang, Lu [1 ,2 ]
Schnabl, Bernd [1 ,2 ]
机构：
[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[2] VA San Diego Healthcare Syst, Dept Med, San Diego, CA USA
来源：
PHYSIOLOGY | 2020年 / 35卷 / 04期
基金：
美国国家卫生研究院;
关键词：
microbiome; bile acids; short-chain fatty acids; non-alcoholic fatty liver disease; alcoholic liver disease; CHAIN FATTY-ACIDS; PRIMARY BILIARY-CIRRHOSIS; TRIMETHYLAMINE N-OXIDE; DIET-INDUCED OBESITY; BILE-ACID; NONALCOHOLIC STEATOHEPATITIS; TRYPTOPHAN-METABOLISM; INTESTINAL MICROBIOTA; NUCLEAR RECEPTOR; PROTECTS MICE;
D O I：
10.1152/physiol.00005.2020
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The gut and the liver have a bidirectional communication via the biliary system and the portal vein. The intestinal microbiota and microbial products play an important role for modulating liver diseases such as alcohol-associated liver disease, non-alcoholic fatty liver disease and steatohepatitis, and cholestatic liver diseases. Here, we review the role of the gut microbiota and its products for the pathogenesis and therapy of chronic liver diseases.
引用
收藏
页码：261 / 274
页数：14
相关论文
共 188 条
  • [1] Dysbiosis of oral microbiota and its association with salivary immunological biomarkers in autoimmune liver disease
    Abe, Kazumichi
    Takahashi, Atsushi
    Fujita, Masashi
    Imaizumi, Hiromichi
    Hayashi, Manabu
    Okai, Ken
    Ohira, Hiromasa
    [J]. PLOS ONE, 2018, 13 (07):
  • [2] ANTIBIOTICS PREVENT LIVER-INJURY IN RATS FOLLOWING LONG-TERM EXPOSURE TO ETHANOL
    ADACHI, Y
    MOORE, LE
    BRADFORD, BU
    GAO, WS
    THURMAN, RG
    [J]. GASTROENTEROLOGY, 1995, 108 (01) : 218 - 224
  • [3] Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
    Agus, Allison
    Planchais, Julien
    Sokol, Harry
    [J]. CELL HOST & MICROBE, 2018, 23 (06) : 716 - 724
  • [4] Bacterial lipopolysaccharides and innate immunity
    Alexander, C
    Rietschel, ET
    [J]. JOURNAL OF ENDOTOXIN RESEARCH, 2001, 7 (03): : 167 - 202
  • [5] Alexander J S, 2010, Pathophysiology, V17, P315, DOI 10.1016/j.pathophys.2009.09.003
  • [6] Endotoxin and Plasminogen Activator Inhibitor-1 Serum Levels Associated With Nonalcoholic Steatohepatitis in Children
    Alisi, Anna
    Manco, Melania
    Devito, Rita
    Piemonte, Fiorella
    Nobili, Valerio
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 50 (06) : 645 - 649
  • [7] Aller R, 2011, EUR REV MED PHARMACO, V15, P1090
  • [8] Gene Expression Analysis of a Human Enterocyte Cell Line Reveals Downregulation of Cholesterol Biosynthesis in Response to Short-chain Fatty Acids
    Alvaro, Adriana
    Sola, Rosa
    Rosales, Roser
    Ribalta, Josep
    Anguera, Anna
    Masana, Lluis
    Caries Vallve, Joan
    [J]. IUBMB LIFE, 2008, 60 (11) : 757 - 764
  • [9] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    Backhed, Fredrik
    Manchester, Jill K.
    Semenkovich, Clay F.
    Gordon, Jeffrey I.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) : 979 - 984
  • [10] Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements
    Badawy, Abdulla A-B.
    [J]. NEUROPHARMACOLOGY, 2017, 112 : 248 - 263
12345678910