Chemoselective reduction of pyrimidines. An access to enantiopure tetrahydropyrimidinones

被引：6

作者：

Agami, C ^{[1
]}

Dechoux, L ^{[1
]}

Melaimi, M ^{[1
]}

机构：

[1] Univ Paris 06, UMR 7611, Lab Synthese Asymetr, F-75005 Paris, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 49期

关键词：

1,3-diamines; tetrahydropyrimidinones; chemoselective reduction; pyrimidines;

D O I：

10.1016/S0040-4039(01)01875-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of substituted 1,3-tetrahydropyrimidinones 8 starting from homochiral synthon 2 is described. Chemoselective reduction of pyrimidines 4 using BH3-THF provides an access to regioselective N-protected tetrahydropyrimidinones 8. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8629 / 8631

页数：3

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