The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence

被引：8
作者：
Contu, Lara [1 ,4 ]
Steiner, Silvio [2 ,3 ,4 ]
Thiel, Volker [2 ,3 ]
Muhlemann, Oliver [1 ]
机构：
[1] Univ Bern, Dept Chem & Biochem, Freiestr 3, CH-3012 Bern, Switzerland
[2] Univ Bern, Vetsuisse Fac, Inst Immunol & Virol, Dept Infect Dis & Pathobiol, Langgassstr 122, CH-3012 Bern, Switzerland
[3] Inst Immunol & Virol, Bern, Switzerland
[4] Univ Bern, Grad Sch Cellular & Biomed Sci, Bern, Switzerland
来源：
CHIMIA | 2019年 / 73卷 / 05期
基金：
瑞士国家科学基金会;
关键词：
Innate immune response; Integrated stress response; Nonsense-mediated mRNA decay; RNA virus; Stress granules; TRANSLATION INITIATION; KINASE GCN2; NMD; COMPLEX; DEGRADATION; TRANSCRIPTS; TERMINATION; MECHANISM; UPF1; SEQUESTRATION;
D O I：
10.2533/chimia.2019.374
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic processes that are vital for maintenance of cellular homeostasis -1) the nonsense-mediated mRNA decay (NMD) pathway and 2) the transient formation of stress granules (SG) - and explore the current literature on their roles in antiviral defence. Within the NCCR RNA & Disease, the laboratories of Proffs. O. Muhlemann and Volker Thiel teamed up to unravel the roles of NMD and SGs, and their interconnections in defending cells from alphavirus and coronavirus infections.
引用
收藏
页码：374 / 379
页数：6
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