The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence

被引：8
作者：
Contu, Lara [1 ,4 ]
Steiner, Silvio [2 ,3 ,4 ]
Thiel, Volker [2 ,3 ]
Muhlemann, Oliver [1 ]
机构：
[1] Univ Bern, Dept Chem & Biochem, Freiestr 3, CH-3012 Bern, Switzerland
[2] Univ Bern, Vetsuisse Fac, Inst Immunol & Virol, Dept Infect Dis & Pathobiol, Langgassstr 122, CH-3012 Bern, Switzerland
[3] Inst Immunol & Virol, Bern, Switzerland
[4] Univ Bern, Grad Sch Cellular & Biomed Sci, Bern, Switzerland
来源：
CHIMIA | 2019年 / 73卷 / 05期
基金：
瑞士国家科学基金会;
关键词：
Innate immune response; Integrated stress response; Nonsense-mediated mRNA decay; RNA virus; Stress granules; TRANSLATION INITIATION; KINASE GCN2; NMD; COMPLEX; DEGRADATION; TRANSCRIPTS; TERMINATION; MECHANISM; UPF1; SEQUESTRATION;
D O I：
10.2533/chimia.2019.374
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic processes that are vital for maintenance of cellular homeostasis -1) the nonsense-mediated mRNA decay (NMD) pathway and 2) the transient formation of stress granules (SG) - and explore the current literature on their roles in antiviral defence. Within the NCCR RNA & Disease, the laboratories of Proffs. O. Muhlemann and Volker Thiel teamed up to unravel the roles of NMD and SGs, and their interconnections in defending cells from alphavirus and coronavirus infections.
引用
收藏
页码：374 / 379
页数：6
相关论文
共 75 条
[1]   A faux 3′-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay [J].
Amrani, N ;
Ganesan, R ;
Kervestin, S ;
Mangus, DA ;
Ghosh, S ;
Jacobson, A .
NATURE, 2004, 432 (7013) :112-118
[2]   Stress-specific differences in assembly and composition of stress granules and related foci [J].
Aulas, Anais ;
Fay, Marta M. ;
Lyons, Shawn M. ;
Achorn, Christopher A. ;
Kedersha, Nancy ;
Anderson, Paul ;
Ivanov, Pavel .
JOURNAL OF CELL SCIENCE, 2017, 130 (05) :927-937
[3]   A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay [J].
Baker, Stacey L. ;
Hogg, J. Robert .
PLOS ONE, 2017, 12 (03)
[4]  
Balistreri G., 2017, VIRUSES, V9, P1
[5]   The Host Nonsense-Mediated mRNA Decay Pathway Restricts Mammalian RNA Virus Replication [J].
Balistreri, Giuseppe ;
Horvath, Peter ;
Schweingruber, Christoph ;
Zuend, David ;
McInerney, Gerald ;
Merits, Andres ;
Muehlemann, Oliver ;
Azzalin, Claus ;
Helenius, Ari .
CELL HOST & MICROBE, 2014, 16 (03) :403-411
[6]   Antiviral effect of the mammalian translation initiation factor 2α kinase GCN2 against RNA viruses [J].
Berlanga, Juan J. ;
Ventoso, Ivan ;
Harding, Heather P. ;
Deng, Jing ;
Ron, David ;
Sonenberg, Nahum ;
Carrasco, Luis ;
de Haro, Cesar .
EMBO JOURNAL, 2006, 25 (08) :1730-1740
[7]   A Novel Role for hSMG-1 in Stress Granule Formation [J].
Brown, James A. L. ;
Roberts, Tara L. ;
Richards, Renee ;
Woods, Rick ;
Birrell, Geoff ;
Lim, Y. C. ;
Ohno, Shigeo ;
Yamashita, Akio ;
Abraham, Robert T. ;
Gueven, Nuri ;
Lavin, Martin F. .
MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (22) :4417-4429
[8]   Eukaryotic Stress Granules: The Ins and Outs of Translation [J].
Buchan, J. Ross ;
Parker, Roy .
MOLECULAR CELL, 2009, 36 (06) :932-941
[9]   EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length [J].
Bühler, M ;
Steiner, S ;
Mohn, F ;
Paillusson, A ;
Mühlemann, O .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (05) :462-464
[10]   A REGULATORY MECHANISM THAT DETECTS PREMATURE NONSENSE CODONS IN T-CELL RECEPTOR TRANSCRIPTS IN-VIVO IS REVERSED BY PROTEIN-SYNTHESIS INHIBITORS IN-VITRO [J].
CARTER, MS ;
DOSKOW, J ;
MORRIS, P ;
LI, SL ;
NHIM, RP ;
SANDSTEDT, S ;
WILKINSON, MF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (48) :28995-29003
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