In Vitro Susceptibility of Field Isolates of Leishmania donovani to Miltefosine and Amphotericin B: Correlation with Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity

被引：66

作者：

Kumar, Dhiraj ^{[1
]}

Kulshrestha, Arpita ^{[1
]}

Singh, Ruchi ^{[1
]}

Salotra, Poonam ^{[1
]}

机构：

[1] Inst Pathol ICMR, New Delhi 110029, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 02期

关键词：

PROGRAMMED CELL-DEATH; INDIAN KALA-AZAR; DRUG-RESISTANCE; VISCERAL LEISHMANIASIS; REFRACTORINESS; BIOSYNTHESIS; TRANSPORTER; MECHANISM; PROTEIN;

D O I：

10.1128/AAC.01233-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Indian Leishmania donovani isolates (n = 19) from regional zones representing various levels of antimony resistance displayed significantly (P < 0.01) correlated results with respect to in vitro susceptibility to the antileishmanial drugs sodium antimony gluconate, amphotericin B, and Miltefosine, raising the possibility of cross-resistance mechanisms operating in the field isolates. The results of gene expression analysis of LdMT and LdRos3 were suggestive of alternate mechanisms of Miltefosine susceptibility in the isolates.

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页码：835 / 838

页数：4

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