Hepatitis C virus infection protein network

被引：305

作者：

de Chassey, B. ^{[1
,2
]}

Navratil, V. ^{[2
,3
]}

Tafforeau, L. ^{[1
,2
]}

Hiet, M. S. ^{[1
,2
]}

Aublin-Gex, A. ^{[1
,2
]}

Agaugue, S. ^{[1
,2
]}

Meiffren, G. ^{[1
,2
]}

Pradezynski, F. ^{[1
,2
]}

Faria, B. F. ^{[1
,2
]}

Chantier, T. ^{[1
,2
]}

Le Breton, M. ^{[1
,2
]}

Pellet, J. ^{[1
,2
]}

Davoust, N. ^{[1
,2
]}

Mangeot, P. E. ^{[1
,2
]}

Chaboud, A. ^{[2
,4
]}

Penin, F. ^{[2
,4
]}

Jacob, Y. ^{[5
]}

Vidalain, P. O. ^{[6
]}

Vidal, M. ^{[7
]}

Andre, P. ^{[1
,2
,8
]}

Rabourdin-Combe, C. ^{[1
,2
]}

Lotteau, V. ^{[1
,2
,8
]}

机构：

[1] INSERM, U851, IMAP Team, F-69007 Lyon, France

[2] Univ Lyon, BioSci Lyon Gerland IFR128, Lyon, France

[3] INRA, UMR 754, Lyon, France

[4] CNRS, UMR 5086, Inst Biol & Chim Prot, Lyon, France

[5] Inst Pasteur, Unite Postulante Genet Papillomavirus & Canc Huma, Paris, France

[6] Inst Pasteur, CNRS, URA 3015, Lab Genom Virale & Vaccinat, Paris, France

[7] Harvard Univ, Sch Med, Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA

[8] Hop Croix Rousse, Hosp Civils Lyon, Virol Lab, F-69317 Lyon, France

来源：

MOLECULAR SYSTEMS BIOLOGY | 2008年 / 4卷 / 1期

关键词：

Functional analysis; hepatitis C; interactome; virus-host cell;

D O I：

10.1038/msb.2008.66

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein-protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGF beta pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins.

引用

页数：12

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