Metabolic syndrome and cardiovascular disease following hematopoietic cell transplantation: screening and preventive practice recommendations from CIBMTR and EBMT

被引：53

作者：

DeFilipp, Z. ^{[1
]}

Duarte, R. F. ^{[2
]}

Snowden, J. A. ^{[3
,4
]}

Majhail, N. S. ^{[5
]}

Greenfield, D. M. ^{[6
]}

Miranda, J. L. ^{[7
]}

Arat, M. ^{[8
]}

Baker, K. S. ^{[9
]}

Burns, L. J. ^{[10
]}

Duncan, C. N. ^{[11
]}

Gilleece, M. ^{[12
]}

Hale, G. A. ^{[13
]}

Hamadani, M. ^{[14
]}

Hamilton, B. K. ^{[5
]}

Hogan, W. J. ^{[15
]}

Hsu, J. W. ^{[16
]}

Inamoto, Y. ^{[17
]}

Kamble, R. T. ^{[18
]}

Lupo-Stanghellini, M. T. ^{[19
]}

Malone, A. K. ^{[20
]}

McCarthy, P. ^{[21
]}

Mohty, M. ^{[22
,23
,24
]}

Norkin, M.

Paplham, P. ^{[21
]}

Ramanathan, M. ^{[25
]}

Richart, J. M. ^{[26
]}

Salooja, N. ^{[27
]}

Schouten, H. C. ^{[28
]}

Schoemans, H. ^{[29
,30
]}

Seber, A. ^{[31
,32
]}

Steinberg, A. ^{[20
]}

Wirk, B. M. ^{[16
,33
]}

Wood, W. A. ^{[34
]}

Battiwalla, M. ^{[35
]}

Flowers, M. E. D. ^{[9
]}

Savani, B. N. ^{[36
]}

Shaw, B. E. ^{[14
]}

机构：

[1] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA

[2] Hosp Univ Puerta Hierro Majadahonda, Madrid, Spain

[3] Univ Sheffield, Sheffield Teaching Hosp NHS Fdn Trust, Dept Haematol, Sheffield, S Yorkshire, England

[4] Univ Sheffield, Dept Oncol & Metab, Sheffield, S Yorkshire, England

[5] Cleveland Clin, Dept Hematol & Oncol, Cleveland, OH 44106 USA

[6] Sheffield Teaching Hosp NHS Fdn Trust, Specialized Canc Serv, Shefflied, England

[7] Univ Cordoba, Maimonides Inst Biomed Res Cordoba IMIBIC, Reina Sofia Univ Hosp,Dept Med, CIBER Fisiopatol Obesidad Nutr CIBEROB,Inst Salud, Cordoba, Spain

[8] Florence Nightingale Sisli Hosp, Hematopoiet Stem Cell Transplantat Unit, Istanbul, Turkey

[9] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA

[10] Univ Minnesota, Natl Marrow Donor Program, Minneapolis, MN USA

[11] Dana Farber Canc Inst, Pediat Stem Cell Transplant, Boston, MA 02115 USA

[12] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England

[13] John Hopkins Med, All Childrens Hosp, St Petersburg, FL USA

[14] Med Coll Wisconsin, Dept Med, CIBMTR, 9200W Wisconsin Ave, Milwaukee, WI 53226 USA

[15] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA

[16] Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL 32610 USA

[17] Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[18] Baylor Coll Med, Div Hematol & Oncol, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[19] Ist Sci San Raffaele, Hematol & Bone Marrow Transplantat Unit, Milan, Italy

[20] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Hematol Oncol, New York, NY 10029 USA

[21] Roswell Pk Canc Inst, BMT Program, Dept Med, Buffalo, NY 14263 USA

[22] Univ Paris 06, Paris, France

[23] Hop St Antoine, AP HP, Paris, France

[24] INSERM, UMRs 938, Paris, France

[25] UMass Mem Med Ctr, Dept Hematol Oncol & Bone Marrow Transplant, Worcester, MA USA

[26] St Louis Univ, Dept Internal Med, Div Hematol & Med Oncol, St Louis, MO 63103 USA

[27] Hammersmith Hosp, London, England

[28] Maastricht Univ, Med Ctr, Maastricht, Netherlands

[29] Univ Hosp Leuven, Dept Hematol, Leuven, Belgium

[30] Katholieke Univ Leuven, Leuven, Belgium

[31] Hosp Samaritano, Sao Paulo, Brazil

[32] Assoc Medula Ossea AMEO, Sao Paulo, Brazil

[33] SUNY Stony Brook, Med Ctr, Dept Internal Med, Stony Brook, NY 11794 USA

[34] Univ N Carolina, Dept Med, Div Hematol Oncol, Chapel Hill, NC USA

[35] NIH, Hematol Branch, Bldg 10, Bethesda, MD 20892 USA

[36] Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA

来源：

BONE MARROW TRANSPLANTATION | 2017年 / 52卷 / 02期

关键词：

LONG-TERM SURVIVORS; BONE-MARROW-TRANSPLANTATION; BODY-COMPOSITION ABNORMALITIES; IMPAIRED GLUCOSE-TOLERANCE; RISK-FACTORS; DIABETES-MELLITUS; HEMATOLOGIC MALIGNANCIES; SCIENTIFIC STATEMENT; CEREBRAL INFARCTION; PEDIATRIC SURVIVORS;

D O I：

10.1038/bmt.2016.203

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Metabolic syndrome (MetS) is a constellation of cardiovascular risk factors that increases the risk of cardiovascular disease, diabetes mellitus and all cause mortality. Long-term survivors of hematopoietic cell transplantation (HCT) have a substantial risk of developing MetS and cardiovascular disease, with the estimated prevalence of MetS being 31-49% among HCT recipients. Although MetS has not yet been proven to impact cardiovascular risk after HCT, an understanding of the incidence and risk factors for MetS in HCT recipients can provide the foundation to evaluate screening guidelines and develop interventions that may mitigate cardiovascular-related mortality. A working group was established through the Center for International Blood and Marrow Transplant Research and the European Group for Blood and Marrow Transplantation with the goal of reviewing literature and recommend practices appropriate to HCT recipients. Here we deliver consensus recommendations to help clinicians provide screening and preventive care for MetS and cardiovascular disease among HCT recipients. All HCT survivors should be advised of the risks of MetS and encouraged to undergo recommended screening based on their predisposition and ongoing risk factors.

引用

页码：173 / 182

页数：10

共 97 条

[1] Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].

Alberti, K. G. M. M. ;

Eckel, Robert H. ;

Grundy, Scott M. ;

Zimmet, Paul Z. ;

Cleeman, James I. ;

Donato, Karen A. ;

Fruchart, Jean-Charles ;

James, W. Philip T. ;

Loria, Catherine M. ;

Smith, Sidney C., Jr. .

CIRCULATION, 2009, 120 (16) :1640-1645

[2] The metabolic syndrome - a new worldwide definition [J].

Alberti, KGMM ;

Zimmet, P ;

Shaw, J .

LANCET, 2005, 366 (9491) :1059-1062

[3]

Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO

[4]

2-S

[5] Body composition assessment for the definition of cardiometabolic risk [J].

Amato, M. C. ;

Guarnotta, V. ;

Giordano, C. .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2013, 36 (07) :537-543

[6] Prevalence of metabolic syndrome in long-term survivors of hematopoietic stem cell transplantation [J].

Annaloro, C. ;

Usardi, P. ;

Airaghi, L. ;

Giunta, V. ;

Forti, S. ;

Orsatti, A. ;

Baldini, M. ;

Delle Volpe, A. ;

Deliliers, G. Lambertenghi .

BONE MARROW TRANSPLANTATION, 2008, 41 (09) :797-804

[7]

[Anonymous], 2010, DIABETES CARE, DOI DOI 10.2337/dc10-s062

[8]

[Anonymous], HAEMATOLOGICA

[9]

[Anonymous], 2005, The IDF consensus worldwide definition of the metabolic syndrome

[10]

[Anonymous], BMJ CLIN EVID

← 1 2 3 4 5 6 7 8 9 10 →