Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells

被引：13
|
作者：
Liu, Weiwei [1 ]
Jin, Guorong [1 ]
Long, Chongde [1 ]
Zhou, Xin [1 ]
Tang, Yan [2 ]
Huang, Shan [1 ]
Kuang, Xielan [3 ]
Wu, Lizi [4 ]
Zhang, Qingjiong [1 ]
Shen, Huangxuan [1 ]
机构：
[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China
[2] Dalian Med Univ, Inst Canc Stem Cell, Dalian 116023, Peoples R China
[3] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Biobank Eye, Guangzhou 510060, Guangdong, Peoples R China
[4] Univ Florida, Dept Mol Genet & Microbiol, Shands Canc Ctr, Gainesville, FL 32610 USA
来源：
SCIENTIFIC WORLD JOURNAL | 2013年
基金：
中国国家自然科学基金;
关键词：
CANCER; DIFFERENTIATION; PATHWAY; INVOLVEMENT; INDUCTION; EFFECTORS;
D O I：
10.1155/2013/178708
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Notch signaling is an evolutionarily conserved cell-cell communication pathway that plays critical roles in the proliferation, survival, apoptosis, and fate determination of mammalian cells. Retinal pigment epithelial (RPE) cells are responsible for supporting the function of the neural retina and maintaining vision. This study investigated the function of Notch signaling in RPE cells. We found that the members of the Notch signaling pathway components were differentially expressed in RPE cells. Furthermore, blockage of Notch signaling inhibited the migration and proliferation of RPE cells and reduced the expression levels of certain Notch signaling target genes, including HES1, MYC, HEY2, and SOX9. Our data reveal a critical role of Notch signaling in RPE cells, suggesting that targeting Notch signaling may provide a novel approach for the treatment of ophthalmic diseases related to RPE cells.
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页数：6
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