Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins

被引：20

作者：

Rodrigues, Igor A. ^{[1
]}

Ramos, Aline de S. ^{[2
]}

Falcao, Deborah Q. ^{[3
]}

Ferreira, Jose Luiz P. ^{[2
,3
]}

Basso, Silvia L. ^{[4
]}

Silva, Jefferson Rocha de A. ^{[5
]}

Amaral, Ana Claudia F. ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Sch Pharm, Dept Nat Prod & Food, BR-21941590 Rio De Janeiro, RJ, Brazil

[2] Lab Med Plants & Derivat, Rua Sizenando Nabuco 100, BR-21041250 Rio De Janeiro, RJ, Brazil

[3] Fed Fluminense Univ, Pharm Fac, R Dr Mario Vianna 523, BR-24241002 Niteroi, RJ, Brazil

[4] FUNTAC, Av Acacias,Lote 01,Zona A, BR-69917100 Rio Branco, AC, Brazil

[5] Univ Fed Amazonas, Chem Dept, Chromatog Lab, Av Rodrigo Otavio 3000, BR-6907700 Manaus, Amazonas, Brazil

来源：

BIOMED RESEARCH INTERNATIONAL | 2018年 / 2018卷

关键词：

MULTIJUGA HAYNE; COPAIBA OIL; IN-VIVO; LEISHMANIA-AMAZONENSIS; BETA-CARYOPHYLLENE; DELIVERY MODES; NANO-EMULSIONS; REQUIRED HLB; CONSTITUENTS; AGENT;

D O I：

10.1155/2018/9781724

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Based on the ethnopharmacological evidences about the antileishmanial activity of Copaifera spp. oleoresins, the effects of crude extracts and fractions of oleoresin of two specimens from Copaifera paupera were evaluated on Leishmania amazonensis and Leishmania infantum strains. The oleoresin rich in alpha-copaene (38.8%) exhibited the best activity against L. amazonensis (IC50 = 62.5 mu g/mL) and against L. infantum (IC50 = 65.9 mu g/mL). The sesquiterpene alpha-copaene isolated was tested alone and exhibited high antileishmanial activity in vitro with IC50 values for L. amazonensis and L. infantum of 17.2 and 11.4 mu g/mL, respectively. In order to increase antileishmanial activity, nanoemulsions containing copaiba oleoresin and alpha-copaene were developed and assayed against L. amazonensis and L. infantum promastigotes. The nanoemulsion containing alpha-copaene (NANOCOPAEN) showed the best activity against both species, with IC50 of 2.5 and 2.2 mu g/mL, respectively. This is the first report about the antileishmanial activity of alpha-copaene.

引用

页数：9

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