Kinetics of self-assembling microtubules: An ''inverse problem'' in biochemistry

被引:143
作者
Flyvbjerg, H
Jobs, E
Leibler, S
机构
[1] PRINCETON UNIV, DEPT PHYS, PRINCETON, NJ 08544 USA
[2] PRINCETON UNIV, DEPT MOLEC BIOL, PRINCETON, NJ 08544 USA
[3] RISO NATL LAB, DEPT OPT & FLUID DYNAM, DK-4000 ROSKILDE, DENMARK
关键词
D O I
10.1073/pnas.93.12.5975
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Experimental time series for a nonequilibrium reaction may in some cases contain sufficient data to determine a unique kinetic model for the reaction by a systematic mathematical analysis. As an example, a kinetic model for the self-assembly of microtubules is derived here from turbidity time series for solutions in which microtubules assemble. The model may be seen as a generalization of Oosawa's classical nucleation-polymerization model. it reproduces the experimental data with a four-stage nucleation process and a critical nucleus of 15 monomers.
引用
收藏
页码:5975 / 5979
页数:5
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