Antimicrobial Activity of Stable Silver Nanoparticles of a Certain Size

被引：86

作者：

Mukha, Iu. P. ^{[1
]}

Eremenko, A. M. ^{[1
]}

Smirnova, N. P. ^{[1
]}

Mikhienkova, A. I. ^{[2
]}

Korchak, G. I. ^{[2
]}

Gorchev, V. F. ^{[3
]}

Chunikhin, A. Yu. ^{[3
]}

机构：

[1] Natl Acad Sci Ukraine, Chuiko Inst Surface Chem, UA-03164 Kiev 164, Ukraine

[2] AN Marzeev Inst Hyg & Med Ecol NAMS Ukraine, UA-02660 Kiev 94, Ukraine

[3] AV Palladin Inst Biochem NAS Ukraine, UA-01601 Kiev 601, Ukraine

来源：

APPLIED BIOCHEMISTRY AND MICROBIOLOGY | 2013年 / 49卷 / 02期

关键词：

AQUEOUS-SOLUTION; RESISTANCE; KINETICS; BURN;

D O I：

10.1134/S0003683813020117

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Conditions for obtaining stable silver nanoparticles smaller than 10 nm were developed using a binary stabilizer polyvinylpyrrolidone/sodium dodecylsulphate in optimal ratio. Optical spectra, morphology and dependence of size of the nanoparticles on the amount of reducing agent were studied. Colloidal solutions of nanosilver showed a high bactericidal activity against strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, and fungicidal activity against Candida albicans. The mechanism of action of nanosized silver on microbial cell was examined by laser scanning confocal microscope using fluorescent label. First step of antimicrobial effect on microorganisms was membrane damage and penetration of silver nanoparticles into the cell. Prolonged stability of nanoparticles and their antimicrobial activity over the past two years were showed.

引用

页码：199 / 206

页数：8

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