Targeting minor histocompatibility antigens in graft versus tumor or graft versus leukemia responses

被引：39

作者：

Feng, Xin ^{[1
,2
]}

Hui, Kwok Min ^{[1
,2
]}

Younes, Hashem M. ^{[1
,2
]}

Brickner, Anthony G. ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15213 USA

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 12期

关键词：

D O I：

10.1016/j.it.2008.09.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allogeneic hematopoietic cell transplantation (alloHCT) represents the only curative therapy for several hematologic malignancies, and shows promise as a nascent treatment modality for select solid tumors. Although the original goal of alloHCT was hematopoietic reconstitution after sub-lethal chemoradiotherapy, recognition of a profound donor lymphocyte-mediated graft-versus-leukemia (GVL) or graft-versus-tumor (GVT) effect has shifted the paradigm from pre-transplant cytoreduction to tumor control via donor lymphocytes. In human leukocyte antigen (HLA)-compatible alloHCT, GVL and GVT reactions are induced primarily by donor T-cell recognition of minor histocompatibility antigens (mHAgs). Here we review the literature regarding mHAg-specific T cells in GVL and GVT reactions, and discuss the prospects of exploiting mHAgs as immunotherapeutic targets.

引用

页码：624 / 632

页数：9

共 96 条

[1] Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling [J].

Akatsuka, Y ;

Warren, EH ;

Gooley, TA ;

Brickner, AG ;

Lin, MT ;

Hansen, JA ;

Martin, PJ ;

Madtes, DK ;

Engelhard, VH ;

Takahashi, T ;

Riddell, SR .

BRITISH JOURNAL OF HAEMATOLOGY, 2003, 123 (04) :671-675

[2] Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens [J].

Akatsuka, Y ;

Nishida, T ;

Kondo, E ;

Miyazaki, M ;

Taji, H ;

Iida, H ;

Tsujimura, K ;

Yazaki, M ;

Naoe, T ;

Morishima, Y ;

Kodera, Y ;

Kuzushima, K ;

Takahashi, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (11) :1489-1500

[3] Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease [J].

Anderson, BE ;

McNiff, JM ;

Matte, C ;

Athanasiadis, I ;

Shlomchik, WD ;

Shlomchik, MJ .

BLOOD, 2004, 104 (05) :1565-1573

[4] The current status of hematopoietic cell transplantation [J].

Appelbaum, FR .

ANNUAL REVIEW OF MEDICINE-SELECTED TOPICS IN THE CLINICAL SCIENCES, 2003, 54 :491-512

[5] Stem cell transplantation with reduced-intensity conditioning regimens: a review of ten years experience with new transplant concepts and new therapeutic agents [J].

Barrett, A. J. ;

Savani, B. N. .

LEUKEMIA, 2006, 20 (10) :1661-1672

[6] CD4(+) and CD8(+) T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex disparate recipients [J].

Blazar, BR ;

Taylor, PA ;

Vallera, DA .

TRANSPLANTATION, 1997, 64 (04) :571-576

[7] Molecules and mechanisms of the graft-versus-leukaemia effect [J].

Bleakley, M ;

Riddell, SR .

NATURE REVIEWS CANCER, 2004, 4 (05) :371-380

[8] CD8+ minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells [J].

Bonnett, D ;

Warren, EH ;

Greenberg, PD ;

Dick, JE ;

Riddell, SR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8639-8644

[9] The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL [J].

Brickner, AG ;

Evans, AM ;

Mito, JK ;

Xuereb, SM ;

Feng, X ;

Nishida, T ;

Fairfull, L ;

Ferrell, RE ;

Foon, KA ;

Hunt, DF ;

Shabanowitz, J ;

Engelhard, VH ;

Riddell, SR ;

Warren, EH .

BLOOD, 2006, 107 (09) :3779-3786

[10] The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing [J].

Brickner, AG ;

Warren, EH ;

Caldwell, JA ;

Akatsuka, Y ;

Golovina, TN ;

Zarling, AL ;

Shabanowitz, J ;

Eisenlohr, LC ;

Hunt, DF ;

Engelhard, VH ;

Riddell, SR .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (02) :195-205

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