AN EFFICIENT SOLVENT- AND CATALYST-FREE SYNTHESIS OF BICYCLIC PYRIDONES WITH HIGH MOLECULAR DIVERSITY VIA CASCADE REACTION

被引：4

作者：

Fu, Huang-Mei ^{[1
,2
]}

Wang, Hong-Bin ^{[1
]}

Yang, Li-Juan ^{[1
]}

Yang, Wen-Rong ^{[2
]}

Huang, Chao ^{[1
]}

机构：

[1] Yunnan Minzu Univ, Sch Chem & Environm, Engn Res Ctr Biopolymer Funct Mat Yunnan, Kunming 650500, Yunnan, Peoples R China

[2] Deakin Univ, Ctr Chem & Biotechnol, Sch Life & Environm Sci, Geelong, Vic 3216, Australia

来源：

HETEROCYCLES | 2018年 / 96卷 / 02期

关键词：

HETEROCYCLIC KETENE AMINALS; ALZHEIMERS-DISEASE; INHIBITORS; DERIVATIVES; HUPERZINE;

D O I：

10.3987/COM-17-13849

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two efficient cascade routes for synthesis of substituted bicyclic pyridines under solvent- and catalyst-free conditions have been developed. One is conducted by refluxing the reaction mixture of heterocyclic ketene aminals (HKAs), triethoxymethane and dicarbonyl compounds. The other one is proceeded with HKAs and diethyl ethoxymethylenemalonate (EMME) under ultrasound irradiation. Both routes for preparation of bicyclic 2-pyridones carried out with low cost and easy available substrates and achieved diversity of target compounds in good yields efficiently and environmental-friendly.

引用

页码：311 / 323

页数：13

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