Elements of biological oscillations in time and space

被引：36
作者：
Cao, Yangxiaolu [1 ]
Lopatkin, Allison [1 ]
You, Lingchong [1 ,2 ,3 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA
[2] Duke Univ, Ctr Genom & Computat Biol, Durham, NC 27708 USA
[3] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27708 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 12期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
GENE-EXPRESSION; CELL-CYCLE; PATTERN-FORMATION; ESCHERICHIA-COLI; VERTEBRATE SEGMENTATION; CLOCK; DIVISION; MODEL; NOISE; DYNAMICS;
D O I：
10.1038/nsmb.3320
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oscillations in time and space are ubiquitous in nature and play critical roles in dynamic cellular processes. Although the molecular mechanisms underlying the generation of the dynamics are diverse, several distinct regulatory elements have been recognized as being critical in producing and modulating oscillatory dynamics. These include negative and positive feedback, time delay, nonlinearity in regulation, and random fluctuations ('noise'). Here we discuss the specific roles of these five elements in promoting or attenuating oscillatory dynamics, by drawing on insights from quantitative analyses of natural or synthetic biological networks.
引用
收藏
页码：1030 / 1034
页数：5
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