Total synthesis of eucryphin and its glycosylation derivatives

被引：1

作者：

Zhang, Yucheng ^{[1
]}

Liu, Jiahao ^{[1
]}

Xing, Hongxia ^{[2
]}

Huang, Yaxuan ^{[1
]}

Yao, Qian ^{[1
]}

Kang, Tairan ^{[2
]}

Guo, Xiaoqiang ^{[1
]}

机构：

[1] Chengdu Univ, Sichuan Ind Inst Antibiot, Sch Pharm, Chengdu 610106, Peoples R China

[2] Chengdu Univ, Sch Food & Biol Engn, Chengdu 610106, Peoples R China

来源：

TETRAHEDRON | 2022年 / 122卷

关键词：

Eucryphin; Chromone; Glycosylation; Total synthesis; CHROMONE GLYCOSIDE; INHIBITORS; EFFECTORS; RHIZOMES;

D O I：

10.1016/j.tet.2022.132949

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of eucryphin and its five glycosyl-modified derivatives from commercially available phloroglucinol was first developed. The key step for the synthesis of eucryphin relies on selective oxidation to form a hydroxyl group at the C-3 position of chromone by using iodosobenzene diacetate reagent. The methodology may be utilized in the synthesis of functional chromone derivatives.(c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：7

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