Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits

被引：36

作者：

Soares, Bruna V. ^{[1
]}

Morais, Selene M. ^{[1
,2
]}

dos Santos Fontenelle, Raquel Oliveira ^{[3
]}

Queiroz, Vanessa A. ^{[2
]}

Vila-Nova, Nadja S. ^{[1
]}

Pereira, Christiana M. C. ^{[2
]}

Brito, Edy S. ^{[4
]}

Neto, Manoel A. S. ^{[4
]}

Brito, Erika H. S. ^{[5
]}

Cavalcante, Carolina S. P. ^{[5
]}

Castelo-Branco, Debora S. C. M. ^{[1
,6
]}

Rocha, Marcos F. G. ^{[1
,6
]}

机构：

[1] Univ Estadual Ceara, Postgrad Program Vet Sci, BR-60740000 Fortaleza, Ceara, Brazil

[2] Univ Estadual Ceara, Dept Chem, BR-60740000 Fortaleza, Ceara, Brazil

[3] Acarau Valley State Univ, Ctr Agr Sci & Biol, BR-62040370 Sobral, CE, Brazil

[4] Embrapa Trop Agroind Ctr, BR-89700000 Fortaleza, Ceara, Brazil

[5] Super Inst Appl Theol, Fac Vet Med, Dept Vet, BR-62050100 Sobral, CE, Brazil

[6] Univ Fed Ceara, Specialized Med Mycol Ctr, Sch Med, Dept Pathol & Legal Med, BR-60441750 Fortaleza, Ceara, Brazil

来源：

MOLECULES | 2012年 / 17卷 / 07期

关键词：

Coriandrum sativum; essential oil; Microsporum canis; Candida spp; Artemia salina; linalool; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL; PRODUCTS; ARTEMIA; STRAINS; AGENTS;

D O I：

10.3390/molecules17078439

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from C. sativum L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC50 value of 23 mu g/mL in the Artemia salina lethality test. The antifungal activity was evaluated against Microsporum canis and Candida spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 +/- 5.42 and 9.25 +/- 0.5 for M. canis and Candida spp. respectively. The MICs and MFCs for M. canis strains ranged from 78 to 620 and 150 to 1,250 mu g/mL, and the MICs and MFCs for Candida spp strains ranged from 310 to 620 and 620 to 1,250 mu g/mL, respectively. C. sativum essential oil is active in vitro against M. canis and Candida spp. demonstrating good antifungal activity.

引用

页码：8439 / 8448

页数：10

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