Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography

被引：18

作者：

Liu, Fei ^{[1
]}

Cao, Xu ^{[1
]}

He, Wei ^{[1
]}

Song, Jinping ^{[2
]}

Dai, Zhongquan ^{[2
]}

Zhang, Bin ^{[1
]}

Luo, Jianwen ^{[1
,3
]}

Li, Yinghui ^{[2
]}

Bai, Jing ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Biomed Engn, Beijing 100084, Peoples R China

[2] China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China

[3] Tsinghua Univ, Ctr Biomed Imaging Res, Beijing 100084, Peoples R China

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2012年 / 17卷 / 04期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

fluorescence molecular tomography; reflection; reconstruction; therapeutic response;

D O I：

10.1117/1.JBO.17.4.040504

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Subsurface fluorescence molecular tomography (FMT) has promising potential for noninvasive characterization of molecular and cellular activities in small animals by tomographic means in reflectance geometry. In this work, subsurface FMT is employed to monitor the therapeutic response of cisplatin in tumor-bearing mice in vivo. The localization and quantification accuracy of subsurface FMT are demonstrated in phantom. In the in vivo study, the red fluorescent protein activities not only on the surface but in the interior tumor are tracked three-dimensionally during the antitumor treatment. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.4.040504]

引用

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