Genetic diversity among Mycobacterium bovis isolates:: A preliminary study of strains from animal and human sources

被引：18

作者：

Sales, MPU

Taylor, GM

Hughes, S

Yates, M

Hewinson, G

Young, DB

Shaw, RJ

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis & Microbiol, London SW7 2AZ, England

[2] Natl Heart & Lung Inst, Dept Resp Med, London SW7 2AZ, England

[3] Vet Lab Agcy, Addlestone KT15 3NB, Surrey, England

[4] Kings Coll London Hosp, Kings Coll Sch Med & Dent, Mycobacterium Ref Unit, Publ Hlth Lab Serv, London SE22 8QF, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2001年 / 39卷 / 12期

关键词：

D O I：

10.1128/JCM.39.12.4558-4562.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis.

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页码：4558 / 4562

页数：5

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