Transfusion Reactions Newer Concepts on the Pathophysiology, Incidence, Treatment, and Prevention of Transfusion-Related Acute Lung Injury

被引:30
作者
Sayah, David M. [1 ]
Looney, Mark R. [2 ]
Toy, Pearl [3 ]
机构
[1] Univ Calif San Francisco, Dept Med, Div Pulm Crit Care Allergy & Sleep Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Med & Lab Med, Div Pulm Crit Care Allergy & Sleep Med, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
关键词
Transfusion-related acute lung injury; Acute lung injury; Transfusion reaction; Multiple transfusions; Pulmonary edema; RED-BLOOD-CELLS; CLASS-II; CIGARETTE-SMOKING; ROUTINE STORAGE; PLASMA; ANTIBODY; LIPIDS; RISK; ACTIVATION; PATIENT;
D O I
10.1016/j.ccc.2012.04.001
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. TRALI presents as acute lung injury (ALI) within 6 hours after blood product transfusion. Diagnosing TRALI requires a high index of suspicion, and the exclusion of circulatory overload or other causes of ALI. The pathophysiology of TRALI is incompletely understood, but in part involves transfusion of certain anti-neutrophil antibodies, anti-HLA antibodies, or other bioactive substances, into susceptible recipients. Recent studies have identified both recipient and transfusion risk factors for the development of TRALI. This article describes these TRALI risk factors, as well as diagnosis, treatment and prevention strategies.
引用
收藏
页码:363 / +
页数:11
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