Conversion of Graded Presynaptic Climbing Fiber Activity into Graded Postsynaptic Ca2+ Signals by Purkinje Cell Dendrites

被引:25
作者
Gaffield, Michael A. [1 ]
Bonnan, Audrey [1 ]
Christie, Jason M. [1 ]
机构
[1] Max Planck Florida Inst Neurosci, Jupiter, FL 33458 USA
基金
美国国家卫生研究院;
关键词
CALCIUM SIGNALS; COMPLEX-SPIKE; OSCILLATIONS; PLASTICITY; CHANNELS;
D O I
10.1016/j.neuron.2019.03.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts of sensory-associated external cues in a graded manner, apparent in the presynaptic activity of their axonal projections (climbing fibers) in the cerebellar cortex. Individual climbing fibers were broadly responsive to different sensory modalities but relayed sensory-related information to the cortex in a lobule-dependent manner. Purkinje cell dendrites faithfully transformed this climbing fiber activity into dendrite-wide Ca2+ signals without a direct contribution from the mossy fiber pathway. These results demonstrate that the size of climbing-fiber-evoked Ca2+ signals in Purkinje cell dendrites is largely determined by the firing level of climbing fibers. This coding scheme emphasizes the overwhelming role of the inferior olive in generating salient signals useful for instructing plasticity and learning.
引用
收藏
页码:762 / +
页数:12
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