Heroin addiction engages negative emotional learning brain circuits in rats

被引：37

作者：

Carmack, Stephanie A. ^{[1
,3
]}

Keeley, Robin J. ^{[2
]}

Vendruscolo, Janaina C. M. ^{[1
]}

Lowery-Gionta, Emily G. ^{[1
]}

Lu, Hanbing ^{[2
]}

Koob, George F. ^{[1
]}

Stein, Elliot A. ^{[2
]}

Vendruscolo, Leandro F. ^{[1
]}

机构：

[1] NIDA, Integrat Neurosci Res Branch, Intramural Res Program, NIH, Baltimore, MD USA

[2] NIDA, Neuroimaging Res Branch, Intramural Res Program, NIH, Baltimore, MD USA

[3] George Mason Univ, Ctr Adapt Syst Brain Body Interact, Fairfax, VA 22030 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 06期

基金：

加拿大健康研究院;

关键词：

PITUITARY-ADRENAL AXIS; OPIATE WITHDRAWAL; DRUG; NEUROCIRCUITRY; DEPENDENCE; NALOXONE;

D O I：

10.1172/JCI125534

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Opioid use disorder is associated with the emergence of persistent negative emotional states during drug abstinence that drive compulsive drug taking and seeking. Functional magnetic resonance imaging (fMRI) in rats identified neurocircuits that were activated by stimuli that were previously paired with heroin withdrawal. The activation of amygdala and hypothalamic circuits was related to the degree of heroin dependence, supporting the significance of conditioned negative affect in sustaining compulsive-like heroin seeking and taking and providing neurobiological insights into the drivers of the current opioid crisis.

引用

页码：2480 / 2484

页数：5

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