Synthesis and Spectral Properties of Water-Soluble Indocyanine Dyes as Well as the Interaction with DNA and BSA

被引：0

作者：

Zhang, Xiufu ^{[1
]}

Fu, Yile ^{[2
]}

Zuo, Zhijun ^{[1
]}

Hou, Yuan ^{[1
]}

Li, Yuexuan ^{[1
]}

Liu, Yanxia ^{[1
]}

Wang, Lanying ^{[1
]}

机构：

[1] Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Peoples R China

[2] Xian Univ Architecture & Technol, Sch Sci, Xian 710055, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 33卷 / 08期

关键词：

water-soluble indocyanine dye; spectral properties; DNA; BSA; CYANINE; ABSORPTION;

D O I：

10.6023/cjoc201212042

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six novel water-soluble indocyanine dyes were synthesized using 1,2,3-trimethyl-3-(4-sulphobutyl)-3H-indolium-5-sulphonate salt and corresponding aromatic aldehyde as materials and piperidine as catalyst. All of the compounds were characterized by H-1 NMR, HRMS, IR and UV-vis techniques. Their spectral properities in different solvents were also investigated. The results showed that the maximum absorption wavelength of the dyes was in the region of 426.0 similar to 562.5 nm, the emission wavelength was located in 508.2 similar to 596.0 nm and the molar extinction coefficients was in the region of 0.6x10(4)similar to 6.7x10(4) L.mol(-1).cm(-1) in different solvents. The interactions of prepared dyes with salmon sperm DNA and bovine serum albumin (BSA) were also investigated. The results showed that the interaction of five water-soluble dyes with DNA or BSA was weak.

引用

页码：1709 / 1714

页数：6

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