Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

被引：47
|
作者：
Gisbert-Garzaran, M. [1 ,2 ]
Lozano, D. [1 ,2 ]
Vallet-Regi, M. [1 ,2 ]
Manzano, M. [1 ,2 ]
机构：
[1] Univ Complutense Madrid, Inst Invest Sanitaria Hosp, Fac Farm, Dept Quim Inorgan & Bioinorgan, 12 Octubre I 12,Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain
[2] Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Madrid, Spain
来源：
RSC ADVANCES | 2017年 / 7卷 / 01期
基金：
欧洲研究理事会;
关键词：
MESOPOROUS SILICA NANOPARTICLES; RELEASE; NANOTECHNOLOGY; DEGRADATION; THERAPY; SYSTEMS;
D O I：
10.1039/c6ra26771h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.
引用
收藏
页码：132 / 136
页数：5
相关论文
共 50 条
  • [21] Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery
    Wang, Lin
    Shi, Xuefeng
    Zhang, Jian
    Zhu, Yuejun
    Wang, Jinben
    RSC ADVANCES, 2018, 8 (55): : 31581 - 31587
  • [22] Drug self-gating fluorescent nanoparticles for pH-responsive doxorubicin delivery
    Li, Guoling
    Yang, Bo
    Gu, Chuantao
    JOURNAL OF MATERIALS SCIENCE, 2020, 55 (02) : 738 - 747
  • [23] Biodegradable Cyclomatrix Polyphosphazene Nanoparticles: A Novel pH-Responsive Drug Self-Framed Delivery System
    Hou, Shenglei
    Chen, Shuangshuang
    Dong, Yuan
    Gao, Su
    Zhu, Bangshang
    Lu, Qinghua
    ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (31) : 25983 - 25993
  • [24] Preparation and application of pH-responsive drug delivery systems
    Ding, Haitao
    Tan, Ping
    Fu, Shiqin
    Tian, Xiaohe
    Zhang, Hu
    Ma, Xuelei
    Gu, Zhongwei
    Luo, Kui
    JOURNAL OF CONTROLLED RELEASE, 2022, 348 : 206 - 238
  • [25] Redox- and pH-responsive hydrogels: formulation and controlled drug delivery
    Yu, Lili
    Yao, Lin
    Yang, Kuan
    JOURNAL OF POROUS MATERIALS, 2016, 23 (06) : 1581 - 1589
  • [26] 1,2-oxazine linker as a thermal trigger for self-immolative polymers
    Peterson, Gregory I.
    Church, Derek C.
    Yakelis, Neal A.
    Boydston, Andrew J.
    POLYMER, 2014, 55 (23) : 5980 - 5985
  • [27] PEGylated hollow pH-responsive polymeric nanocapsules for controlled drug delivery
    Massoumi, Bakhshali
    Abbasian, Mojtaba
    Jahanban-Esfahlan, Rana
    Motamedi, Sanaz
    Samadian, Hadi
    Rezaei, Aram
    Derakhshankhah, Hossein
    Farnudiyan-Habibi, Amir
    Jaymand, Mehdi
    POLYMER INTERNATIONAL, 2020, 69 (05) : 519 - 527
  • [28] Synthesis of self-assemble pH-responsive cyclodextrin block copolymer for sustained anticancer drug delivery
    Lu, Bei-bei
    Wei, Lu-lu
    Meng, Gui-hua
    Hou, Jun
    Liu, Zhi-yong
    Guo, Xu-hong
    CHINESE JOURNAL OF POLYMER SCIENCE, 2017, 35 (08) : 924 - 938
  • [29] Multiresponsive Azobenzene End-Cap for Self-Immolative Polymers
    Wong, Andrew D.
    Guengoer, Thomas M.
    Gillies, Elizabeth R.
    ACS MACRO LETTERS, 2014, 3 (11): : 1191 - 1195
  • [30] pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery
    Sun, Henglai
    Li, Xinyu
    Liu, Qian
    Sheng, Huagang
    Zhu, Liqiao
    JOURNAL OF DRUG TARGETING, 2024, 32 (06) : 672 - 706
12345