Self-immolative polymers as novel pH-responsive gate keepers for drug delivery

被引：47
|
作者：
Gisbert-Garzaran, M. [1 ,2 ]
Lozano, D. [1 ,2 ]
Vallet-Regi, M. [1 ,2 ]
Manzano, M. [1 ,2 ]
机构：
[1] Univ Complutense Madrid, Inst Invest Sanitaria Hosp, Fac Farm, Dept Quim Inorgan & Bioinorgan, 12 Octubre I 12,Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain
[2] Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Madrid, Spain
来源：
RSC ADVANCES | 2017年 / 7卷 / 01期
基金：
欧洲研究理事会;
关键词：
MESOPOROUS SILICA NANOPARTICLES; RELEASE; NANOTECHNOLOGY; DEGRADATION; THERAPY; SYSTEMS;
D O I：
10.1039/c6ra26771h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.
引用
收藏
页码：132 / 136
页数：5
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