Periventricular Spread of Primary Central Nervous System T-cell Lymphoma in a Cat

被引：12

作者：

Morita, T. ^{[1
]}

Kondo, H. ^{[1
]}

Okamoto, M. ^{[2
]}

Park, C. H. ^{[3
]}

Sawashima, Y. ^{[4
]}

Shimada, A. ^{[1
]}

机构：

[1] Tottori Univ, Dept Vet Pathol, Tottori 6808553, Japan

[2] Rakuno Gakuen Univ, Dept Vet Pathol, Sch Vet Med, Ebetsu, Hokkaido 0698501, Japan

[3] Kitasato Univ, Dept Vet Pathol, Sch Vet Med & Anim Sci, Aomori 0348628, Japan

[4] Sawashima Vet Clin, Kobe, Hyogo 6540034, Japan

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2009年 / 140卷 / 01期

关键词：

cat; central nervous system; primary lymphoma; T-cell; IMMUNOPROLIFERATIVE LESION; BORNA-DISEASE; GRANULOMATOSIS; MENINGOENCEPHALOMYELITIS;

D O I：

10.1016/j.jcpa.2008.09.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 9-year-old domestic shorthaired cat with clinical signs of neurological disease was determined to have primary T-cell lymphoma of the central nervous system (CNS) oil necropsy examination. Microscopically, neoplastic lymphocytes were distributed in the CNS parenchyma bilaterally around the cerebral ventricles, third ventricle, mesencephalic aqueduct, fourth ventricle and central canal of the spinal cord. The neoplastic infiltration was associated with complete loss of ependymal cells and marked astrocytosis. A large, solitary neoplastic lesion was present in the parenchyma around the central canal of the spinal cord at the level or the 13th thoracic vertebra. Immunohistochemically, the majority of neoplastic cells expressed CD3 and many also labelled for proliferating cell nuclear antigen (PCNA) and Ki-67. This is, to our knowledge, the first report of periventricular spread of primary CNS T-cell lymphoma in animals. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：54 / 58

页数：5

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