Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization

被引：24

作者：

Amato, Dahlia N. ^{[1
]}

Amato, Douglas V. ^{[1
]}

Mavrodi, Olga V. ^{[2
]}

Martin, William B. ^{[1
]}

Swilley, Sarah N. ^{[1
]}

Parsons, Keith H. ^{[1
]}

Mavrodi, Dmitri V. ^{[2
]}

Patton, Derek L. ^{[1
]}

机构：

[1] Univ Southern Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA

[2] Univ Southern Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA

来源：

ACS MACRO LETTERS | 2017年 / 6卷 / 02期

基金：

美国国家科学基金会;

关键词：

CROSS-LINKED POLYESTERS; CONTROLLED-RELEASE; ANTIBACTERIAL ACTIVITIES; POLYMERIC PRODRUG; EXTENDED-RELEASE; SALICYLIC-ACID; ESSENTIAL OILS; IN-VITRO; ANTIOXIDANT; BEHAVIOR;

D O I：

10.1021/acsmacrolett.7b00009

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAS derived from diallyl p-chlorobenzaldehyde acetal degrade and release p-chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAS enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.

引用

页码：171 / 175

页数：5

共 40 条

[1] Pinosylvin-Based Polymers: Biodegradable Poly(Anhydride-Esters) for Extended Release of Antibacterial Pinosylvin [J].

Bien-Aime, Stephan ;

Yu, Weiling ;

Uhrich, Kathryn E. .

MACROMOLECULAR BIOSCIENCE, 2016, 16 (07) :978-983

[2] Acid-degradable polymers for drug delivery: a decade of innovation [J].

Binauld, Sandra ;

Stenzel, Martina H. .

CHEMICAL COMMUNICATIONS, 2013, 49 (21) :2082-2102

[3]

Burkoth AK, 2000, J BIOMED MATER RES, V51, P352

[4] Essential oils: their antibacterial properties and potential applications in foods - a review [J].

Burt, S .

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2004, 94 (03) :223-253

[5] Poly(anhydride-esters) Comprised Exclusively of Naturally Occurring Antimicrobials and EDTA: Antioxidant and Antibacterial Activities [J].

Carbone-Howell, Ashley L. ;

Stebbins, Nicholas D. ;

Uhrich, Kathryn E. .

BIOMACROMOLECULES, 2014, 15 (05) :1889-1895

[6] Cross-Linked, Biodegradable, Cytocompatible Salicylic Acid Based Polyesters for Localized, Sustained Delivery of Salicylic Acid: An In Vitro Study [J].

Chandorkar, Yashoda ;

Bhagat, Rajesh K. ;

Madras, Giridhar ;

Basu, Bikramjit .

BIOMACROMOLECULES, 2014, 15 (03) :863-875

[7] Controlled Release of Usnic Acid from Biodegradable Polyesters to Inhibit Biofilm Formation [J].

Dasgupta, Queeny ;

Madras, Giridhar ;

Chatterjee, Kaushik .

ACS BIOMATERIALS SCIENCE & ENGINEERING, 2017, 3 (03) :291-303

[8] Controlled release kinetics of p-aminosalicylic acid from biodegradable crosslinked polyesters for enhanced anti-mycobacterial activity [J].

Dasgupta, Queeny ;

Madras, Giridhar ;

Chatterjee, Kaushik .

ACTA BIOMATERIALIA, 2016, 30 :168-176

[9] Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters [J].

Dasgupta, Queeny ;

Chatterjee, Kaushik ;

Madras, Giridhar .

MOLECULAR PHARMACEUTICS, 2015, 12 (09) :3479-3489

[10] Essential oils: From extraction to encapsulation [J].

El Asbahani, A. ;

Miladi, K. ;

Badri, W. ;

Sala, M. ;

Addi, E. H. Ait ;

Casabianca, H. ;

El Mousadik, A. ;

Hartmann, D. ;

Jilale, A. ;

Renaud, F. N. R. ;

Elaissari, A. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 483 (1-2) :220-243

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