Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization

被引：23

作者：

Amato, Dahlia N. ^{[1
]}

Amato, Douglas V. ^{[1
]}

Mavrodi, Olga V. ^{[2
]}

Martin, William B. ^{[1
]}

Swilley, Sarah N. ^{[1
]}

Parsons, Keith H. ^{[1
]}

Mavrodi, Dmitri V. ^{[2
]}

Patton, Derek L. ^{[1
]}

机构：

[1] Univ Southern Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA

[2] Univ Southern Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA

来源：

ACS MACRO LETTERS | 2017年 / 6卷 / 02期

基金：

美国国家科学基金会;

关键词：

CROSS-LINKED POLYESTERS; CONTROLLED-RELEASE; ANTIBACTERIAL ACTIVITIES; POLYMERIC PRODRUG; EXTENDED-RELEASE; SALICYLIC-ACID; ESSENTIAL OILS; IN-VITRO; ANTIOXIDANT; BEHAVIOR;

D O I：

10.1021/acsmacrolett.7b00009

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAS derived from diallyl p-chlorobenzaldehyde acetal degrade and release p-chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAS enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.

引用

页码：171 / 175

页数：5

共 40 条

[1] Pinosylvin-Based Polymers: Biodegradable Poly(Anhydride-Esters) for Extended Release of Antibacterial Pinosylvin
Bien-Aime, Stephan
Yu, Weiling
Uhrich, Kathryn E.
[J]. MACROMOLECULAR BIOSCIENCE, 2016, 16 (07) : 978 - 983
[2] Acid-degradable polymers for drug delivery: a decade of innovation
Binauld, Sandra
Stenzel, Martina H.
[J]. CHEMICAL COMMUNICATIONS, 2013, 49 (21) : 2082 - 2102
[3] Burkoth AK, 2000, J BIOMED MATER RES, V51, P352
[4] Essential oils: their antibacterial properties and potential applications in foods - a review
Burt, S
[J]. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2004, 94 (03) : 223 - 253
[5] Poly(anhydride-esters) Comprised Exclusively of Naturally Occurring Antimicrobials and EDTA: Antioxidant and Antibacterial Activities
Carbone-Howell, Ashley L.
Stebbins, Nicholas D.
Uhrich, Kathryn E.
[J]. BIOMACROMOLECULES, 2014, 15 (05) : 1889 - 1895
[6] Cross-Linked, Biodegradable, Cytocompatible Salicylic Acid Based Polyesters for Localized, Sustained Delivery of Salicylic Acid: An In Vitro Study
Chandorkar, Yashoda
Bhagat, Rajesh K.
Madras, Giridhar
Basu, Bikramjit
[J]. BIOMACROMOLECULES, 2014, 15 (03) : 863 - 875
[7] Controlled Release of Usnic Acid from Biodegradable Polyesters to Inhibit Biofilm Formation
Dasgupta, Queeny
Madras, Giridhar
Chatterjee, Kaushik
[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING, 2017, 3 (03): : 291 - 303
[8] Controlled release kinetics of p-aminosalicylic acid from biodegradable crosslinked polyesters for enhanced anti-mycobacterial activity
Dasgupta, Queeny
Madras, Giridhar
Chatterjee, Kaushik
[J]. ACTA BIOMATERIALIA, 2016, 30 : 168 - 176
[9] Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters
Dasgupta, Queeny
Chatterjee, Kaushik
Madras, Giridhar
[J]. MOLECULAR PHARMACEUTICS, 2015, 12 (09) : 3479 - 3489
[10] Essential oils: From extraction to encapsulation
El Asbahani, A.
Miladi, K.
Badri, W.
Sala, M.
Addi, E. H. Ait
Casabianca, H.
El Mousadik, A.
Hartmann, D.
Jilale, A.
Renaud, F. N. R.
Elaissari, A.
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 483 (1-2) : 220 - 243

← 1 2 3 4 →