Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia

被引：18

作者：

Khazanov, V. A. ^{[1
]}

Kiseliova, A. A. ^{[1
]}

Vasiliev, K. Yu. ^{[1
]}

Chernyschova, G. A. ^{[2
]}

机构：

[1] Russian Acad Med Sci, Mol Pharmacol Lab, Grp Pharmacol Kinet, Tomsk, Russia

[2] Russian Acad Med Sci, Lab Circulat Pharmacol, Inst Pharmacol, Tomsk Res Ctr,Siberian Div, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 146卷 / 02期

关键词：

acute myocardial ischemia; myocardial mitochondria; succinic acid; malic acid;

D O I：

10.1007/s10517-008-0259-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A mixture of mitochondrial substrates of succinic and malic acids more effectively than antihypoxant trimetazidine prevented functional and metabolic disorders in rat myocardium during acute ischemia: reduces T wave amplitude, QT interval, number and duration of arrhythmias, and restores oxidation-phosphorylation coupling.

引用

页码：218 / 222

页数：5

共 7 条

[1] Medical progress: Sudden death due to cardiac arrhythmias [J].

Huikuri, HV ;

Castellanos, A ;

Myerburg, RJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (20) :1473-1482

[2] The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase [J].

Kantor, PF ;

Lucien, A ;

Kozak, R ;

Lopaschuk, GD .

CIRCULATION RESEARCH, 2000, 86 (05) :580-588

[3]

KHAZANOV VA, 2007, B EKSP BIOL MED S, V1, P35

[4]

KHAZANOV VA, 2003, B EKSP BIOL MED S, V2, P40

[5]

Olbinskaya LI, 2000, KARDIOLOGIYA, V40, P91

[6]

SERGEEV VP, 1991, B EKSP BIOL MED, V62, P381

[7]

2004, DRUG REGISTER RUSSIA

← 1 →