Glutathione S-transferase M1 and T1 gene polymorphisms with consumption of high fruit-juice and vegetable diet affect antioxidant capacity in healthy adults

被引:18
作者
Yuan, Linhong [1 ]
Zhang, Ling [2 ]
Ma, Weiwei [1 ]
Zhou, Xin [1 ]
Ji, Jian [1 ]
Li, Nan [1 ]
Xiao, Rong [1 ]
机构
[1] Capital Med Univ, Sch Publ Hlth & Family Med, Beijing, Peoples R China
[2] Zhejiang Acad Med Sci, Inst Hlth Food, Hangzhou, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
GST; Genetic polymorphism; Fruit and vegetable; Dietary intervention; Antioxidant capacity; OXIDATIVE DNA-DAMAGE; VITAMIN-C; HUMAN-LYMPHOCYTES; BIOMARKERS; WOMEN; STRESS; REPAIR; INTERVENTION; DISEASE; IMPACT;
D O I
10.1016/j.nut.2012.12.025
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: To our knowledge, no data have yet shown the combined effects of GSTM1/GSTT1 gene polymorphisms with high consumption of a fruit and vegetable diet on the body's antioxidant capacity. A 2-wk dietary intervention in healthy participants was conducted to test the hypothesis that the antioxidant biomarkers in individuals with different glutathione-S-transferases (GST) genotypes will be different in response to a high fruit-juice and vegetable diet. Methods: In our study, 24 healthy volunteers with different GST genotypes (12 GSTM1+/GSTT1+ and 12 GSTM1-/GSTT1- participants) consumed a controlled diet high in fruit-juice and vegetables for 2 wk. Blood and first-void urine specimens were obtained at baseline, 1-wk, and 2-wk intervals. The antioxidant capacity-related biomarkers in blood and urine were observed and recorded at the scheduled times. Results: Erythrocyte GST and glutathione reductase (GR) activities response to a high fruit-juice and vegetable diet are GST genotype-dependent. Two weeks on the high fruit-juice and vegetable diet increased GST and GR activities in the GSTM1+/GSTT1+ group (P < 0.05 compared with baseline or GSTNI1-/GSTT1-group), although no effects were observed on GST and GR activities in GSTM1-/GSTT1- participants. Dietary intervention increased total antioxidant capacity and decreased plasma malondialdehyde content in all participants (P < 0.05 compared with baseline), whereas GSTM1+/GSTT1+ participants respond more quickly to a high fruit-juice and vegetable diet than GSTM1-/GSTT1- participants. The diet intervention was effective in enhancing glutathione peroxidase and catalase activities in all participants (P < 0.05 compared with baseline), although there was no influence on erythrocyte superoxide dismutase activity (P > 0.05). Conclusion: The effects of a diet rich in fruit-juice and vegetables on antioxidant capacity were dependent on GSTM1/GSTT1 genotypes. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:965 / 971
页数:7
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