Zonation of hepatic bile salt transporters

被引：12

作者：

Baier, PK ^{[1
]}

Hempel, S ^{[1
]}

Waldvogel, B ^{[1
]}

Baumgartner, U ^{[1
]}

机构：

[1] Univ Freiburg, Dept Surg, D-79106 Freiburg, Germany

来源：

DIGESTIVE DISEASES AND SCIENCES | 2006年 / 51卷 / 03期

关键词：

metabolic zonation; hepatic bile salt transporters; nuclear factors;

D O I：

10.1007/s10620-006-3174-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pericentral and periportal hepatocytes differ in their capacity to eliminate and velocity of eliminating bile acids and other organic anions. We wonder whether differences in the distribution of anion transporters (ntcp [M77479], besp [NM-031760], mrp2 [NM-012833], oatp1 [NM-017111], oatp2 [NM-131906]) cause the differences in bile acid excretion. Therefore, we analyzed the distribution of these anion transporters in periportal and pericentral cells by immunohistology, their mRNA by quantitative PCR, and regulating nuclear factors (NF-kappa B, HNF1, HNF3, HNF4, FXR, PXR) by gel shift assay. We did not find any differences in nuclear factors or regarding the proteins that could explain the zonal differences in anion transport.

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收藏

页码：587 / 593

页数：7

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