Dopamine (DRD2) and Serotonin (HTR2A, 2C) Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia

被引：11
作者：
Alladi, Charanraj Goud [1 ,2 ,3 ]
RajKumar, Ravi Philip [4 ]
Adithan, Surendiran [1 ]
Marie-Claire, Cynthia [2 ,3 ]
Bellivier, Frank [2 ,3 ,5 ,6 ]
Shewade, Deepak Gopal [1 ]
机构：
[1] Jawaharlal Inst Postgrad Med Educ & Res, Dept Pharmacol, Pondicherry 605006, India
[2] INSERM, U1144, F-75006 Paris, France
[3] Univ Sorbonne Paris Cite, UMR S 1144, F-75006 Paris, France
[4] Jawaharlal Inst Postgrad Med Educ & Res, Dept Psychiat, Pondicherry 605006, India
[5] GH St Louis Lariboisiere F Widal, AP HP, Pole Psychiat & Med Addictol, F-75475 Paris 10, France
[6] Fdn FondaMental, F-94000 Creteil, France
来源：
FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2019年 / 33卷 / 03期
关键词：
dopamine; genetic polymorphism; risperidone; schizophrenia; serotonin; ANTIPSYCHOTIC-DRUG TREATMENT; 5-HT2A RECEPTOR; CLINICAL-RESPONSE; THERAPEUTIC RESPONSE; CLOZAPINE RESPONSE; NEGATIVE SYMPTOMS; PROMOTER REGION; 1ST-EPISODE SCHIZOPHRENIA; ALLELIC VARIATION; ASSOCIATION;
D O I：
10.1111/fcp.12424
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Treatment response to antipsychotic drugs is variable and conflicting results have been obtained while studying the influence of DRD2 and HTR2 genetic variants on antipsychotic drug efficacy. To explore further, the present study aimed to assess the influence of DRD2 -141 C Ins/Del, Taq1A and HTR2A -1438 G/A, 102T/C and HTR2C -759 C/T genetic polymorphisms in response to risperidone in patients with schizophrenia. The study was conducted among the n = 320 South Indian patients with schizophrenia who received risperidone treatment (4-8 mg per day) for a minimum of four weeks. Genotyping was done by real-time PCR. Antipsychotic response was assessed using CGI-I score in cross-sectional group, PANSS score in prospective group at baseline and after receiving the risperidone therapy. DRD2 -141 C Ins/Del (n = 310, Ins/Ins = 177, Ins/Del+ Del/Del = 133, OR 0.70, 95% CI 0.4-1.2 p 0.2), Taq1A (n = 320, AA = 35, AG = 132, GG = 153, p 0.2), HTR2A -1438 G/A (n = 320, AA = 39, AG = 164, GG = 117, p 0.2), HTR2A 102T/C (n = 320, CC = 115, CT = 165, TT = 40, p 0.1) HTR2C -759 C/T (females n = 132, CC = 65, CT+TT = 67, OR 1.3, 95% CI 0.6-2.8, p 0.5; males n = 186, C = 120, T = 66, OR 1.2, 95% CI 0.6-2.4, p 0.4) genetic polymorphisms did not show any association with antipsychotic response to risperidone. DRD2 -141 C Ins/Del, Taq1A, HTR2A -1438 G/A, 102T/C and HTR2C -759 C/T genetic variants are not associated with antipsychotic response to risperidone.
引用
收藏
页码：355 / 364
页数：10
相关论文
共 50 条
[11]   Efficacy of Inhibitory Control in Antisaccade Task and the Polymorphisms of DRD2 Dopamine Receptor Gene in Schizophrenic Patients [J].
Storozheva Z.I. ;
Brodyansky V.M. ;
Kirenskaya A.V. ;
Tkachenko A.A. ;
Kibitov A.O. .
Human Physiology, 2018, 44 (6) :720-724
[12]   Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression [J].
Myers, Regina L. ;
Airey, David C. ;
Manier, D. Hal ;
Shelton, Richard C. ;
Sanders-Bush, Elaine .
BIOLOGICAL PSYCHIATRY, 2007, 61 (02) :167-173
[13]   Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia [J].
Al Hadithy, A. F. Y. ;
Ivanova, S. A. ;
Pechlivanoglou, P. ;
Semke, A. ;
Fedorenko, O. ;
Kornetova, E. ;
Ryadovaya, L. ;
Brouwers, J. R. B. J. ;
Wilffert, B. ;
Bruggeman, R. ;
Loonen, A. J. M. .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2009, 33 (03) :475-481
[14]   Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder [J].
Unschuld, Paul G. ;
Ising, Marcus ;
Erhardt, Angelika ;
Lucae, Susanne ;
Kloiber, Stefan ;
Kohli, Martin ;
Salyakina, Daria ;
Welt, Tobias ;
Kern, Nikola ;
Lieb, Roselind ;
Uhr, Manfred ;
Binder, Elisabeth B. ;
Mueller-Myhsok, Bertram ;
Holsboer, Florian ;
Keck, Martin E. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2007, 144B (04) :424-429
[15]   Association of Serotonin2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia [J].
Li, Jiang ;
Hashimoto, Hitoshi ;
Meltzer, Herbert Y. .
FRONTIERS IN PSYCHIATRY, 2019, 10
[16]   Serotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients [J].
Małgorzata Wrzosek ;
Andrzej Jakubczyk ;
Michał Wrzosek ;
Halina Matsumoto ;
Jacek Łukaszkiewicz ;
Kirk J. Brower ;
Marcin Wojnar .
Pharmacological Reports, 2012, 64 (2) :449-453
[17]   Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients [J].
Maffioletti, Elisabetta ;
Valsecchi, Paolo ;
Minelli, Alessandra ;
Magri, Chiara ;
Bonvicini, Cristian ;
Barlati, Stefano ;
Sacchetti, Emilio ;
Vita, Antonio ;
Gennarelli, Massimo .
DRUG DEVELOPMENT RESEARCH, 2020, 81 (06) :754-761
[18]   Effects of the Interaction of the ANKK1/DRD2 TaqIA and HTR2C Cys23Ser Polymorphisms on Approach Motivation in Schizophrenia Patients and Healthy People [J].
Alfimova M.V. ;
Korovaitseva G.I. ;
Lezheiko T.V. ;
Golubev S.A. ;
Snegireva A.A. ;
Sakharova E.A. ;
Golimbet V.E. .
Neuroscience and Behavioral Physiology, 2019, 49 (8) :1032-1037
[19]   Investigating DRD2 and HTR2A polymorphisms in treatment-resistant schizophrenia: a comparative analysis with other treatment-resistant mental disorders and the healthy state [J].
Del Casale, Antonio ;
Gentile, Giovanna ;
Lardani, Simone ;
Modesti, Martina Nicole ;
Arena, Jan Francesco ;
Zocchi, Clarissa ;
De Luca, Ottavia ;
Parmigiani, Giovanna ;
Angeletti, Gloria ;
Ferracuti, Stefano ;
Preissner, Robert ;
Simmaco, Maurizio ;
Borro, Marina ;
Pompili, Maurizio .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2025,
[20]   Association of DRD2, DRD4 and COMT genes variants and their gene-gene interactions with antipsychotic treatment response in patients with schizophrenia [J].
Taheri, Narges ;
Pirboveiri, Rokhshid ;
Sayyah, Mehdi ;
Bijanzadeh, Mahdi ;
Ghandil, Pegah .
BMC PSYCHIATRY, 2023, 23 (01)
12345