Synthesis and evaluation of antimicrobial activity of hydrazones derived from 3-oxido-1H-imidazole-4-carbohydrazides

被引：74

作者：

Pieczonka, Adam M. ^{[1
]}

Strzelczyk, Aleksandra ^{[2
]}

Sadowska, Beata ^{[3
]}

Mloston, Grzegorz ^{[1
]}

Staczek, Pawel ^{[2
]}

机构：

[1] Univ Lodz, Dept Organ & Appl Chem, Fac Chem, PL-91403 Lodz, Poland

[2] Univ Lodz, Dept Microbial Genet, Fac Biol & Environm Protect, PL-90237 Lodz, Poland

[3] Univ Lodz, Chair Immunol & Infect Biol, Fac Biol & Environm Protect, PL-90237 Lodz, Poland

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 64卷

关键词：

Imidazole N-oxides; Carbohydrazide hydrazones; Antimicrobial activity; Cytotoxicity; RESISTANT STAPHYLOCOCCUS-AUREUS; BIOLOGICAL-ACTIVITIES; ANTIBACTERIAL DRUGS; NITROFURANTOIN; POTENT; DERIVATIVES; IMIDAZOLES;

D O I：

10.1016/j.ejmech.2013.04.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this work we reported the synthesis and evaluation of in vitro antimicrobial activities of hydrazones 6 obtained from 3-oxido-1H-imidazole-4-carbohydrazides 4. All new compounds were characterized by spectroscopic methods. Hydrazones 6 were tested for their in vitro antimicrobial activity against four Gram-positive and four Gram-negative strains of bacteria as well as one fungal species. Three of the tested compounds appeared to be promising agents against reference strains of Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis. They were also tested against twelve clinical isolates of S. aureus and their cytotoxic effect on murine fibroblasts and HeLa human tumor cell line was determined. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：389 / 395

页数：7

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