Genomic integrity and the ageing brain

被引：132
作者：
Chow, Hei-man [1 ,2 ,3 ]
Herrup, Karl [1 ,2 ]
机构：
[1] Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China
[3] Hong Kong Univ Sci & Technol, Inst Adv Study, Kowloon, Hong Kong, Peoples R China
来源：
NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 11期
基金：
美国国家卫生研究院;
关键词：
NEURONAL CELL-DEATH; DNA-DAMAGE RESPONSE; AMYLOID PRECURSOR PROTEIN; HISTONE H2AX PHOSPHORYLATION; NIJMEGEN BREAKAGE SYNDROME; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; ATAXIA-TELANGIECTASIA; DOUBLE-STRAND; OXIDATIVE STRESS;
D O I：
10.1038/nrn4020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
DNA damage is correlated with and may drive the ageing process. Neurons in the brain are postmitotic and are excluded from many forms of DNA repair; therefore, neurons are vulnerable to various neurodegenerative diseases. The challenges facing the field are to understand how and when neuronal DNA damage accumulates, how this loss of genomic integrity might serve as a 'time keeper' of nerve cell ageing and why this process manifests itself as different diseases in different individuals.
引用
收藏
页码：672 / 684
页数：13
相关论文
共 202 条
[1]   MicroRNAs and neurodegeneration: role and impact [J].
Abe, Masashi ;
Bonini, Nancy M. .
TRENDS IN CELL BIOLOGY, 2013, 23 (01) :30-36
[2]   ON SOMATIC RECOMBINATION IN THE CENTRAL-NERVOUS-SYSTEM OF TRANSGENIC MICE [J].
ABELIOVICH, A ;
GERBER, D ;
TANAKA, O ;
KATSUKI, M ;
GRAYBIEL, AM ;
TONEGAWA, S .
SCIENCE, 1992, 257 (5068) :404-408
[3]   MiR-26b, Upregulated in Alzheimer's Disease, Activates Cell Cycle Entry, Tau-Phosphorylation, and Apoptosis in Postmitotic Neurons [J].
Absalon, Sabrina ;
Kochanek, Dawn M. ;
Raghavan, Venkatesan ;
Krichevsky, Anna M. .
JOURNAL OF NEUROSCIENCE, 2013, 33 (37) :14645-14659
[4]   miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis [J].
Adlakha, Y. K. ;
Saini, N. .
CELL DEATH & DISEASE, 2013, 4 :e542-e542
[5]   Selective Cell Death of Hyperploid Neurons in Alzheimer's Disease [J].
Arendt, Thomas ;
Brueckner, Martina K. ;
Mosch, Birgit ;
Loesche, Andreas .
AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (01) :15-20
[6]   Initiating cellular stress responses [J].
Bakkenist, CJ ;
Kastan, MB .
CELL, 2004, 118 (01) :9-17
[7]   DNA damage checkpoints: from initiation to recovery or adaptation [J].
Bartek, Jiri ;
Lukas, Jiri .
CURRENT OPINION IN CELL BIOLOGY, 2007, 19 (02) :238-245
[8]   Meiotic recombination in mammals: localization and regulation [J].
Baudat, Frederic ;
Imai, Yukiko ;
de Massy, Bernard .
NATURE REVIEWS GENETICS, 2013, 14 (11) :794-806
[9]   TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease [J].
Bender, Andreas ;
Desplats, Paula ;
Spencer, Brian ;
Rockenstein, Edward ;
Adame, Anthony ;
Elstner, Matthias ;
Laub, Christoph ;
Mueller, Sarina ;
Koob, Andrew O. ;
Mante, Michael ;
Pham, Emily ;
Klopstock, Thomas ;
Masliah, Eliezer .
PLOS ONE, 2013, 8 (04)
[10]   Neural mechanisms of ageing and cognitive decline [J].
Bishop, Nicholas A. ;
Lu, Tao ;
Yankner, Bruce A. .
NATURE, 2010, 464 (7288) :529-535
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