Cell-Free DNA: An Upcoming Biomarker in Transplantation

被引：137

作者：

Gielis, E. M. ^{[1
,2
]}

Ledeganck, K. J. ^{[1
]}

De Winter, B. Y. ^{[1
]}

Del Favero, J. ^{[3
]}

Bosmans, J. -L. ^{[1
,4
]}

Claas, F. H. J. ^{[2
]}

Abramowicz, D. ^{[1
,4
]}

Eikmans, M. ^{[2
]}

机构：

[1] Univ Antwerp, Lab Expt Med & Pediat, B-2020 Antwerp, Belgium

[2] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, Leiden, Netherlands

[3] Multiplicom NV, Niel, Belgium

[4] Univ Antwerp Hosp, Dept Hypertens & Nephrol, Antwerp, Belgium

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2015年 / 15卷 / 10期

关键词：

ORGAN INTEGRITY BIOMARKER; DONOR-SPECIFIC DNA; CIRCULATING DNA; HUMAN-URINE; GENOMIC DNA; PLASMA DNA; RECIPIENTS; REJECTION; ORIGIN; BLOOD;

D O I：

10.1111/ajt.13387

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

After organ transplantation, donor-derived cell-free DNA (ddcfDNA) can be detected in the recipient's blood and urine. Different ddcfDNA quantification techniques have been investigated but a major breakthrough was made with the introduction of digital droplet PCR and massive parallel sequencing creating the opportunity to increase the understanding of ddcfDNA kinetics after transplantation. The observations of increased levels of ddcfDNA during acute rejection and even weeks to months before histologic features of graft rejection point to a possible role of ddcfDNA as an early, noninvasive rejection marker. In this review, we summarize published research on ddcfDNA in the transplantation field thereby elaborating on its clinical utility.

引用

页码：2541 / 2551

页数：11

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