Clinical observation of umbilical cord mesenchymal stem cell transplantation for treating patients receiving peritoneal dialysis

被引:5
作者
Jiang, Hong-Ying [1 ]
Wang, Jia-Ping [2 ]
Bai, Yi-Hua [1 ]
Yang, Min [1 ]
Zeng, Yi [1 ]
Liao, Yun-Juan [1 ]
He, Zhen-Kun [1 ]
机构
[1] Kunming Med Univ, Hosp Affiliated 2, Dept Nephrol, 374 Dianmian Rd, Kunming 650101, Yunnan, Peoples R China
[2] Kunming Med Univ, Hosp Affiliated 2, Dept Radiol, Kunming, Yunnan, Peoples R China
关键词
Umbilical cord; Mesenchymal stromal cells; Peritoneal dialysis; Therapy; C-reactive protein; Erythropoietin; ISCHEMIA-REPERFUSION; KIDNEY; ERYTHROPOIETIN; THERAPY; DISEASE; REPAIR; RATS;
D O I
10.23736/S0393-2249.17.02869-7
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: This study aims to observe the outcome and safety of umbilical cord-mesenchymal stem cell (UC-MSC) treatment for continuous ambulatory peritoneal dialysis (CAPD) patients. METHODS: A total of 24 CAPD patients, who underwent UC-MSC treatment from June 2011 to December 2012, were selected for this study. These patients were followed up until June 2015. RESULTS: Results revealed a significant increase in hemoglobin, erythropoietin and albumin levels, a decrease in C-reactive protein levels, and marked improvement in cystatin C and urine volume within three months after UC-MSC transplantation; and the difference was statistically significant (P< 0.05). However, the difference in residual glomerular filtration rate, serum creatinine, peritoneal KT/V and remnant kidney KT/V was not statistically significant (P> 0.05). CONCLUSIONS: Clinical indicators of patients with CAPD can be partially improved through UC-MSC treatment.
引用
收藏
页码:95 / 101
页数:7
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