Blocking bleeding: reversing anticoagulant therapy

被引：7

作者：

Ansell, Jack ^{[1
]}

机构：

[1] Lenox Hill Hosp, Dept Med, New York, NY 10021 USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 04期

关键词：

AGENTS;

D O I：

10.1038/nm.3157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new generation of target-specific inhibitors of the coagulation enzymes thrombin and factor Xa has been approved for a number of indications, but the clinical use of these drugs is hindered by the lack of a way to reverse bleeding, should it occur. An antidote to these new oral anticoagulants has now been designed and shows promise in small-animal models of blood loss (pages 446-451).

引用

页码：402 / 404

页数：4

共 12 条

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