KSHV (HHV8) vaccine: promises and potential pitfalls for a new anti-cancer vaccine

被引：36

作者：

Casper, Corey ^{[1
]}

Corey, Lawrence ^{[2
]}

Cohen, Jeffrey, I ^{[3
]}

Damania, Blossom ^{[4
,5
]}

Gershon, Anne A. ^{[6
]}

Kaslow, David C. ^{[7
]}

Krug, Laurie T. ^{[8
]}

Martin, Jeffrey ^{[9
]}

Mbulaiteye, Sam M. ^{[10
]}

Mocarski, Edward S. ^{[11
]}

Moore, Patrick S. ^{[12
]}

Ogembo, Javier Gordon ^{[13
]}

Phipps, Warren ^{[14
,15
]}

Whitby, Denise ^{[16
]}

Wood, Charles ^{[17
]}

机构：

[1] Infect Dis Res Inst, 1616 Eastlake Ave East,Suite 400, Seattle, WA 98102 USA

[2] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1100 Fairview Ave N, Seattle, WA 98109 USA

[3] NIH, Lab Infect Dis, Bldg 50,Room 6134,50 South Dr,MSC8007, Bethesda, MD 20892 USA

[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[6] Columbia Univ, Vagelos Coll Phys & Surg, Dept Pediat, 630 West 168th St, New York, NY 10032 USA

[7] PATH, PATH Essential Med, 2201 Westlake Ave,Suite 200, Seattle, WA USA

[8] NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA

[9] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[10] NCI, Div Canc Epidemiol & Genet, NIH, HHS, 9609 Med Ctr Dr,Rm 6E118 MSC 3330, Bethesda, MD 20892 USA

[11] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[12] Univ Pittsburgh, Hillman Canc Ctr, Canc Virol Program, Pittsburgh, PA 15213 USA

[13] City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunooncol, Duarte, CA 91010 USA

[14] Fred Hutchinson Canc Ctr, Vaccine & Infect Dis Div, Seattle, WA USA

[15] Univ Washington, Dept Med, Div Allergy & Infect Dis, Seattle, WA USA

[16] Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD USA

[17] Louisiana State Univ, Hlth Sci Ctr, Dept Interdisciplinary Oncol, New Orleans, LA 70112 USA

来源：

NPJ VACCINES | 2022年 / 7卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SARCOMA-ASSOCIATED HERPESVIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; EARLY-CHILDHOOD INFECTION; GLYCOPROTEIN-B INTERACTS; KAPOSIS-SARCOMA; ANTIRETROVIRAL THERAPY; CANCER INCIDENCE; HEPARAN-SULFATE; HOMOSEXUAL-MEN; GENE-PRODUCT;

D O I：

10.1038/s41541-022-00535-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Seven viruses cause at least 15% of the total cancer burden. Viral cancers have been described as the "low-hanging fruit" that can be potentially prevented or treated by new vaccines that would alter the course of global human cancer. Kaposi sarcoma herpesvirus (KSHV or HHV8) is the sole cause of Kaposi sarcoma, which primarily afflicts resource-poor and socially marginalized populations. This review summarizes a recent NIH-sponsored workshop's findings on the epidemiology and biology of KSHV as an overlooked but potentially vaccine-preventable infection. The unique epidemiology of this virus provides opportunities to prevent its cancers if an effective, inexpensive, and well-tolerated vaccine can be developed and delivered.

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页数：10

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