Type III secretion of Salmonella enterica serovar Typhimurium translocated effectors and SseFG

被引：74
作者：
Hansen-Wester, I
Stecher, B
Hensel, M
机构：
[1] LMU Munchen, Max von Pettenkofer Inst Hyg & Med Mikrobiol, Lehrstuhl Bakteriol, Munich, Germany
[2] FAU Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, Erlangen, Germany
来源：
INFECTION AND IMMUNITY | 2002年 / 70卷 / 03期
关键词：
D O I：
10.1128/IAI.70.3.1403-1409.2002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The type III secretion system (TTSS) encoded by Salmonella enterica serovar Typhimurium pathogenicity island 2 (SPI2) is employed by Salmonella enterica for interaction with host cells during the intracellular phase of pathogenesis. This TTSS secretes a set of SPI2-encoded proteins in vitro and translocates Salmonella serovar Typhimurium translocated effectors (STE) that are encoded by genes outside of SPI2 into host cells. Using an epitope-tagging approach, we analyzed secretion of proteins by the TTSS of SPI2 and identified SseF and SseG as further secreted substrate proteins. Three members of the STE family, SEA, SifB, and SseJ, were secreted under conditions that also induce secretion of SPI2-encoded substrate proteins.
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页码：1403 / 1409
页数：7
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