Objectives. The objective of this study was to examine the two-body wear resistance of nine different resin denture teeth and one experimental material. Methods. The two-body wear test was performed in a chewing simulator with an antagonistic Al2O3 ball under an axial load of 40 N for 100,000 cycles. In each test series, an enamel sample was included as a reference. The wear was determined with an optical 3D surface profilometer. For statistical evaluation, SPSS for Windows was used. Results. The samples of Artiplus (18.7-SD 21.0) and e-Ha (21.2-SD 15.1) showed the Lowest volumetric wear (in mm(3) x 10(-3)) after 100,000 cycles. The difference from the other materials tested, except NC Veracia Posterior, was statistically significant (p = 0.001-0.037). SR-Postaris-DCL (55.0-SD 6.8), SR-Orthosit-PE (61.1-SD 12.4) and Vitapan (72.1-SD 15.9) exhibited medium-sized wear values with low dispersion, whereas Orthognat (80.1-SD 31.6), Premium 8 (84.6-SD 31.4), NC Veracia Posterior (87.0-SD 52.7), SR-Orthotyp-PE (114.6-SD 28.0) and Trubyte Portrait (123.0-SD 45. 6) showed high wear values with great variations. Statistically provable differences were found between SR-Orthotyp-PE and SR-Postaris-DCL (p=0.019) and also between SR-Orthotyp-PE and SR-Orthosit-PE (p=0.031). For enamel, a medium-sized wear value of 66.1-SD 76.8 was determined. Significance. The denture teeth examined showed differences in two-body wear resistance. The wear values determined were in some cases higher and in others lower than those of natural enamel. A definite connection between the wear resistance and the chemical composition of the materials could not be found in this investigation. (c) 2005 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.