Investigation of of Interaction of Fangchinoline with G-quadruplex DNA by Electrospray Ionization Mass Spectrometry

被引：4
|
作者：
Xu Niu-Sheng [1 ,2 ]
Yang Hong-Mei [1 ,2 ]
Cui Meng [1 ]
Song Feng-Rui [1 ]
Liu Zhi-Qiang [1 ]
Liu Shu-Ying [1 ,3 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
[3] Changchun Univ Chinese Med, Inst Ginseng Res, Changchun 130117, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2012年 / 33卷 / 11期
关键词：
Electrospray ionization mass spectrometry (ESI-MS); Duplex DNA; G-quadruplex; Fangchinoline; Interaction; BINDING; THERAPEUTICS; SEQUENCE; CANCER;
D O I：
10.7503/cjcu20111169
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrospray ionization mass spectrometry (ESI-MS) was used to investigate the interaction of fangchinoline with G-quadruplex and duplex DNA. The results showed that fangchinoline selectively bound to G-quadruplex DNA. Upon MS/MS experiments, complexes of fangchinoline and G-quadruplex DNA underwent the loss of fangchinoline, suggesting an end-stacking binding mode, while complexes of fangchinoline and duplex DNA underwent the loss of fangchinoline, suggesting the intercalated binding mode.
引用
收藏
页码：2430 / 2434
页数：5
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