Investigation of of Interaction of Fangchinoline with G-quadruplex DNA by Electrospray Ionization Mass Spectrometry

被引：4

作者：

Xu Niu-Sheng ^{[1
,2
]}

Yang Hong-Mei ^{[1
,2
]}

Cui Meng ^{[1
]}

Song Feng-Rui ^{[1
]}

Liu Zhi-Qiang ^{[1
]}

Liu Shu-Ying ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Changchun Univ Chinese Med, Inst Ginseng Res, Changchun 130117, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2012年 / 33卷 / 11期

关键词：

Electrospray ionization mass spectrometry (ESI-MS); Duplex DNA; G-quadruplex; Fangchinoline; Interaction; BINDING; THERAPEUTICS; SEQUENCE; CANCER;

D O I：

10.7503/cjcu20111169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrospray ionization mass spectrometry (ESI-MS) was used to investigate the interaction of fangchinoline with G-quadruplex and duplex DNA. The results showed that fangchinoline selectively bound to G-quadruplex DNA. Upon MS/MS experiments, complexes of fangchinoline and G-quadruplex DNA underwent the loss of fangchinoline, suggesting an end-stacking binding mode, while complexes of fangchinoline and duplex DNA underwent the loss of fangchinoline, suggesting the intercalated binding mode.

引用

页码：2430 / 2434

页数：5

共 21 条

[1] G-quadruplex nucleic acids as therapeutic targets
Balasubramanian, Shankar
Neidle, Stephen
[J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2009, 13 (03) : 345 - 353
[2] Evaluation of DNA/Ligand Interactions by Electrospray Ionization Mass Spectrometry
Brodbelt, Jennifer S.
[J]. ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 3, 2010, 3 : 67 - 87
[3] Quadruplex DNA: sequence, topology and structure
Burge, Sarah
Parkinson, Gary N.
Hazel, Pascale
Todd, Alan K.
Neidle, Stephen
[J]. NUCLEIC ACIDS RESEARCH, 2006, 34 (19) : 5402 - 5415
[4] Chu YQ, 2009, CHEM J CHINESE U, V30, P869
[5] Investigation of quadruplex oligonucleotide-drug interactions by electrospray ionization mass spectrometry
David, WM
Brodbelt, J
Kerwin, SM
Thomas, PW
[J]. ANALYTICAL CHEMISTRY, 2002, 74 (09) : 2029 - 2033
[6] Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics - current status and future prospects
Kelland, LR
[J]. EUROPEAN JOURNAL OF CANCER, 2005, 41 (07) : 971 - 979
[7] Lü L, 2011, CHEM J CHINESE U, V32, P863
[8] Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry
Mazzitelli, CL
Brodbelt, JS
Kern, JT
Rodriguez, M
Kerwin, SM
[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2006, 17 (04) : 593 - 604
[9] A hitchhiker's guide to G-quadruplex ligands
Monchaud, David
Teulade-Fichou, Marie-Paule
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (04) : 627 - 636
[10] A HIGHLY CONSERVED REPETITIVE DNA-SEQUENCE, (TTAGGG)N, PRESENT AT THE TELOMERES OF HUMAN-CHROMOSOMES
MOYZIS, RK
BUCKINGHAM, JM
CRAM, LS
DANI, M
DEAVEN, LL
JONES, MD
MEYNE, J
RATLIFF, RL
WU, JR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) : 6622 - 6626

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