Placental transfer and levels of mercury, selenium, vitamin E, and docosahexaenoic acid in maternal and umbilical cord blood

被引:34
|
作者
Sakamoto, Mineshi [1 ,2 ]
Chan, Hing Man [3 ]
Domingo, Jose L. [4 ]
Koriyama, Chihaya [2 ]
Murata, Katsuyuki [5 ]
机构
[1] Natl Inst Minamata Dis, Environm Hlth Sect, Dept Environm Sci & Epidemiol, Minamata, Japan
[2] Kagoshima Univ, Dept Epidemiol & Prevent Med, Grad Sch Med & Dent Sci, Kagoshima, Japan
[3] Univ Ottawa, Dept Biol, Ottawa, ON, Canada
[4] Univ Rovira & Virgili, Sch Med, Lab Toxicol & Environm Hlth, IISPV, Reus, Spain
[5] Akita Univ, Dept Environm Hlth Sci, Grad Sch Med, Akita, Japan
关键词
Methylmercury; Selenium; Vitamin E; Docosahexaenoic acid (DHA); Cord blood; Fetus; POLYUNSATURATED FATTY-ACIDS; METHYLMERCURY EXPOSURE; METHYL MERCURY; OXIDATIVE STRESS; FISH CONSUMPTION; MOTOR FUNCTIONS; FETAL EXPOSURE; HEAVY-METALS; IN-UTERO; TOXICITY;
D O I
10.1016/j.envint.2017.11.001
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Methylmercury (MeHg) is a neurotoxicant known to affect the developing fetal brain as a sensitive target organ. As most mercury (Hg) in blood is MeHg, total mercury (THg) levels in blood are used to estimate the body burden of MeHg. The nutrients selenium (Se), vitamin E, and docosahexaenoic acid (DHA) are protective against MeHg toxicity. We compared maternal and cord blood concentrations of biochemical substances, THg and Se, vitamin E, DHA, and other elements, fatty acids, and amino acids in 54 Japanese mother-newborn pairs to elucidate the fetal risk of MeHg toxicity. Cord blood had higher hematocrit and amino acid values and lower concentrations of lipid components, including fatty acids compared with maternal blood. THg levels in cord blood (7.26 ng/g) were 1.9 times higher than levels in maternal blood (3.79 ng/g). Se concentrations in cord blood (176 ng/g) were slightly higher than concentrations in maternal blood (156 ng/g). Levels of vitamin E (0.31 mg/dL) and DHA (58.8 mu g/mL) in cord blood were much lower than levels in maternal blood (1.38 mg/dL and 147 mu g/mL, respectively). The ratios of Se/THg, vitamin E/THg, and DHA/THg in cord blood were lower than ratios in maternal blood. These results suggest that fetuses are at higher risk to MeHg toxicity.
引用
收藏
页码:309 / 315
页数:7
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