Feline coronavirus antibody titer in cerebrospinal fluid from cats with neurological signs

被引：8

作者：

Soma, Takehisa ^{[1
,2
]}

Saito, Namiko ^{[1
]}

Kawaguchi, Masato ^{[1
]}

Sasai, Kazumi ^{[2
]}

机构：

[1] Marupi Lifetech Co Ltd, Vet Diagnost Lab, 103 Fushiocho, Ikeda, Osaka 5630011, Japan

[2] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Dept Vet Sci, Lab Vet Internal Med, 1-58 Rinku Orai Kita, Izumisano, Osaka 5988531, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2018年 / 80卷 / 01期

关键词：

antibody; CSF; feline coronavirus; RT-PCR; CENTRAL-NERVOUS-SYSTEM; INFECTIOUS PERITONITIS; MULTIPLE-SCLEROSIS; VIRAL ANTIBODY; VIRUS-ANTIBODY; DIAGNOSIS; INDEX; RNA;

D O I：

10.1292/jvms.17-0399

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

To investigate the utility of cerebrospinal fluid (CSF) anti-feline coronavirus (FCoV) antibody test for diagnosis of feline infectious peritonitis (FIP), the antibody titers were tested in CSF and sera from 271 FIP-suspected neurological cats. CSF antibody was detected in 28 cats, which were divided into 2 groups; 15 with CSF titer of 1:80 or lower and 13 with CSF titer of 1:640 or higher. In the latter group, reciprocal serum titer/reciprocal CSF titer was 8 or lower, which is extremely lower than normal range (256-2048), and FCoV RNA was detected in all of 11 CSF samples assayed by RT-PCR. Our findings indicate that CSF titer of 1:640 or higher may be served as a candidate for the index for diagnosing FIP.

引用

页码：59 / 62

页数：4

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