The Link of Interferon Regulatory Factors 4 and 7 on the Patient's Survival in Lung Adenocarcinoma

被引：0

作者：

Kara, Altan ^{[1
]}

Aydin, Ali ^{[1
]}

Morva, Ahsen ^{[1
]}

Ceker, Dilek ^{[1
]}

Kucuker, Sevde ^{[1
]}

Karadag, Abdullah ^{[1
]}

机构：

[1] TUBITAK Marmara Res Ctr, Mol Oncol Lab, Genet Engn & Biotechnol Inst, Gebze, Turkey

来源：

2018 1ST INTERNATIONAL CONFERENCE ON CANCER CARE INFORMATICS (CCI) | 2018年

关键词：

Non-small cell lung adenocarcinoma; IRF4; IRF7; Oncolytic therapy of non-small cell lung adenocarcinoma; Cancer Care Informatics; TRANSCRIPTION FACTORS; IRF FAMILY; CANCER; EXPRESSION; MUTATIONS; DISCOVERY; IMMUNITY; DATABASE; GENES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mechanism behind the development and progression of cancer is complex and largely remained unknown. Recent studies suggest that interferon regulatory factors (IRF) 4 and 7 may play a significant role in carcinogenesis. Alterations on the expression profiles of the IRF4 and IRF7 directly induce pathogen susceptibility in the cell environment resulting in the activation of cancer-related factors required for a number of stages in metastatic cascade. In the present study, we have investigated the role of the IRF4 and IRF7 on the survival of patients with lung adenocarcinoma through genomics and interactome analyses using the data from The Cancer Genome Atlas (TCGA) database. In addition, the possible impact of the damaging mutations on the biological functions of the targeted proteins have been explored.

引用

页码：55 / 58

页数：4

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