The molecular basis for flexibility in the flexible filamentous plant viruses

被引：60

作者：

DiMaio, Frank ^{[1
]}

Chen, Chun-Chieh ^{[2
,3
,4
]}

Yu, Xiong ^{[5
]}

Frenz, Brandon ^{[1
]}

Hsu, Yau-Heiu ^{[4
]}

Lin, Na-Sheng ^{[2
,3
,6
]}

Egelman, Edward H. ^{[5
]}

机构：

[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[2] Acad Sinica, Inst Plant & Microbial Biol, Taipei 115, Taiwan

[3] Acad Sinica, Mol & Biol Agr Sci Program, Taiwan Int Grad Program, Taipei 115, Taiwan

[4] Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 40227, Taiwan

[5] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

[6] Natl Chung Hsing Univ, Ctr Biotechnol, Taichung 40227, Taiwan

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2015年 / 22卷 / 08期

基金：

美国国家卫生研究院;

关键词：

BAMBOO-MOSAIC-VIRUS; COAT PROTEIN; PROTECTIVE IMMUNITY; RNA; POTEXVIRUSES; INDUCTION;

D O I：

10.1038/nsmb.3054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Flexible filamentous plant viruses cause more than half the viral crop damage in the world but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed, owing to the virion's extreme flexibility. We have used cryo-EM to generate an atomic model for bamboo mosaic virus, which reveals flexible N- and C-terminal extensions that allow deformation while still maintaining structural integrity.

引用

页码：642 / 644

页数：3

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